Antibodies, Assay Kits, Biology Cells, cDNA, Clia Kits, Culture Cells, Devices, DNA, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Exosomes, Gels, Isotypes, Medium & Serums, NATtrol, Panel, Particles, PCR, Pcr Kits, Peptides, Reagents, Recombinant Proteins, Ria Kits, RNA, Test Kits, Vector & Virus, Western Blot

Incontinentia pigmenti: multisistemic genodermatosis

Incontinentia pigmenti: multisistemic genodermatosis
Posted by Anna

Incontinence pigmenti is an X-linked genodermatosis generally lethal in males; thus, present almost exclusively in women. It is caused by mutations of loss-of-function in IKBKG (inhibitor of kappa polypeptide enhancer genes in B cells, kinase gamma) gene that prevents the NFкβ (nuclear factor kappa-light-chain-enhancer of B cells activated) protein from migrating into the core to initiate transcription factor that strengthens the body’s immune response and preventing apoptosis.

As a result, the mutant cells become susceptible to apoptosis when exposed to cytokines and, in turn, causes vaso-occlusion and ischemia tissue, such as skin, central nervous system and retina. dermatological lesions are characteristic and occurred in 100% of patients; they are distributed along the lines of Blaschko, which follows the pattern of migration of skin cells in embryogenesis. Skin manifestations follow a sequence of four phases of birth: vesicular, verrucous, hyper- and hypopigmentation. These lesions relevant to this disease because they guide the doctor to diagnosis. In addition, they are accompanied by neurological disorders, such as seizures, and some manifestations of ophthalmology, such as retinal detachment. Incontinence pigmenti patients uncompromised eye drops or clinically significant neurologic prognosis is good and normal life expectancy. This abnormality is permanent, which could be a cause of concern for the patient.


He Incontinence pigmenti es una genodermatosis ligada al cromosoma X, generalmente lethal en los hombres. Está causada por una mutación con Perdida de funcion en el gen IKBKG (inhibitor of kappa polypeptide enhancer genes in B cells kinase gamma), que impide que la protein NFкβ (nuclear factor kappa-light-chain-enhancer of B cells activated) al Migre Nucleo comience y que la transcripción de factores amplifican y la respuesta inmunitaria previenen la apoptosis.

Por tanto, las células Mutantes vuelven vulnerables se cuando la apoptosis child citocinas y provocan expuestas a vaso-oclusión e isquemia de Tejidos como la piel, el sistema nervioso central y la retina. Las lesiones dermatológicas Características child; distribuyen se lo largo de las Líneas de Blaschko, las cuales siguen El Patron de migración de las células de la piel en la embryogenesis, ocurren y en el 100% de los pacientes. Las manifestaciones cutáneas aparecen en una secuencia de cuatro fases inicia que desde el nacimiento: vesicular, verrucosa, hiperpigmentada e hipopigmentada. Estas son lesiones relevantes, orientan al Puesto que hacia el diagnóstico Clinico.

Además, se acompañan de anomalías neurológicas, como convulsivas crisis, oftalmológicas manifestaciones multiples y, como el desprendimiento de la retina. Los pacientes con Incontinence pigmenti, pero sin Compromiso oftalmológico o neurológico clínicamente significativo, Tienen un pronóstico bueno y una esperanza de vida normal. Las anomalías que se presentan permanentes child, lo que puede generar preocupación en los pacientes.

Incontinentia pigmenti: multisistemic genodermatosis
Incontinentia pigmenti: multisistemic genodermatosis

Anti-inflammatory effects of Lasia spinosa Leaf Extract on Lipopolysaccharide-Induced RAW 264.7 macrophages.

Lasia spinosa (L.) Thwaites used as a traditional medicine to treat many inflammatory diseases for centuries. However, its effects on the inflammatory response has not been marked. In this study, we investigated the anti-inflammatory activity of spinosa L. leaf extract in lipopolysaccharide (LPS) -induced RAW 264.7 macrophages. We found that the ethanol extract of the leaves spinosa L. showed anti-oxidant activity because of their high levels of polyphenolic compounds.

Phospho-IκBα-S32 Rabbit mAb

AP0707-20ul 20 ul
EUR 265.2

Phospho-IκBα-S32 Rabbit mAb

AP0707-50ul 50 ul
EUR 369.6

Polyclonal Phospho-BAD(S32) Antibody

APR09137G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Phospho-BAD(S32) . This antibody is tested and proven to work in the following applications:

Rabbit Anti-Human Histone H2A.x (phospho S139) polyclonal Rabbit Antibody

CABT-BL6118 100 ul
EUR 852

Rabbit Anti-Human MEK1/2 (Phospho S217/221) polyclonal antibody

CABT-BL117 100 ul
EUR 702

ATM Phospho (Ser1981) Rabbit Polyclonal Antibody

Ab11236-050 50ul
EUR 416.4

ATM Phospho (Ser1981) Rabbit Polyclonal Antibody

Ab11236-100 100ul
EUR 578.4

PRC1(Phospho-Thr481)Rabbit Polyclonal Antibody

ES8619-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PRC1(Phospho-Thr481)Rabbit from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

PRC1(Phospho-Thr481)Rabbit Polyclonal Antibody

ES8619-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PRC1(Phospho-Thr481)Rabbit from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Rabbit Anti-Rabbit Th Polyclonal Antibody, Phospho-Ser19

CPB-840RR 100 ul
EUR 670.8

Rabbit Anti-Human Lck (Phospho Y416)/FYN (Phospho Y416) polyclonal antibody

CABT-BL118 100 ul
EUR 702

Histone H3(Phospho-Thr3) Rabbit Polyclonal Antibody

12083-100ul 100ul
EUR 302.4

Histone H4(Phospho-Ser1) Rabbit Polyclonal Antibody

12091-100ul 100ul
EUR 302.4

Histone H1(Phospho-Ser1) Rabbit Polyclonal Antibody

12096-100ul 100ul
EUR 302.4

Histone H1(Phospho-Thr3) Rabbit Polyclonal Antibody

12097-100ul 100ul
EUR 302.4

Rabbit Anti-Rabbit SYN1 Polyclonal Antibody, Phospho-Ser9

CPB-795RH 100 ul
EUR 670.8

Histone H3(Phospho-Ser10) Rabbit Polyclonal Antibody

12084-100ul 100ul
EUR 302.4

Histone H3(Phospho-Thr11) Rabbit Polyclonal Antibody

12085-100ul 100ul
EUR 302.4

Histone H3(Phospho-Ser28) Rabbit Polyclonal Antibody

12086-100ul 100ul
EUR 302.4

Histone H3(Phospho-Thr32) Rabbit Polyclonal Antibody

12087-100ul 100ul
EUR 302.4

Histone H3(Phospho-Tyr41) Rabbit Polyclonal Antibody

12088-100ul 100ul
EUR 302.4

Histone H3(Phospho-Thr45) Rabbit Polyclonal Antibody

12089-100ul 100ul
EUR 302.4

Histone H4(Phospho-Ser47) Rabbit Polyclonal Antibody

12092-100ul 100ul
EUR 302.4

Histone H4(Phospho-Thr80) Rabbit Polyclonal Antibody

12093-100ul 100ul
EUR 302.4

IκB-α (Phospho-Tyr42) Polyclonal Conjugated Antibody

C11162 100ul
EUR 476.4

IκB-β (Phospho-Ser23) Polyclonal Conjugated Antibody

C11304 100ul
EUR 476.4

Histone H3(Phospho-Thr118) Rabbit Polyclonal Antibody

12090-100ul 100ul
EUR 302.4

Histone H2B(Phospho-Ser32) Rabbit Polyclonal Antibody

12094-100ul 100ul
EUR 302.4

Histone H2B(Phospho-Ser14) Rabbit Polyclonal Antibody

12102-100ul 100ul
EUR 302.4

Histone H2A(Phospho-Ser129) Rabbit Polyclonal Antibody

12095-100ul 100ul
EUR 302.4

Histone H2A.X(Phospho-Thr120) Rabbit Polyclonal Antibody

12099-100ul 100ul
EUR 302.4

Histone H2A.X(Phospho-Ser139) Rabbit Polyclonal Antibody

12100-100ul 100ul
EUR 302.4

Histone H2A.X(Phospho-Tyr142) Rabbit Polyclonal Antibody

12101-100ul 100ul
EUR 302.4

Rabbit Anti-Rabbit PIK3R1 Polyclonal Antibody, Phospho-Tyr467

CPB-847RH 100 ul
EUR 670.8

Rabbit Anti-Rabbit ERBB3 Polyclonal Antibody, Phospho-Tyr1328

CPB-848RH 100 ul
EUR 670.8

Rabbit Anti-Rabbit PRKCQ Polyclonal Antibody, Phospho-Ser695

CPB-723RH 100 ul
EUR 670.8

Rabbit Anti-Rabbit CTNNB1 Polyclonal Antibody, Phospho-Ser33

CPB-758RH 100 ul
EUR 670.8

Rabbit Anti-Rabbit CTNNB1 Polyclonal Antibody, Phospho-Ser37

CPB-759RH 100 ul
EUR 670.8

Rabbit Anti-Human INSR (Phospho Y1150)/IGF1R (Phospho Y1135) polyclonal antibody

CABT-BL115 100 ul
EUR 702

Rabbit Anti-Rabbit EIF4G1 Polyclonal Antibody, Phospho-Ser1232

CPB-851RH 100 ul
EUR 670.8

Rabbit Anti-Human MYC Polyclonal Antibody, Phospho-Ser62

CPB-826RH 100 ul
EUR 670.8

Rabbit Anti-Human PXN Polyclonal Antibody, Phospho-Tyr88

CPB-859RH 100 ul
EUR 670.8

Rabbit Anti-Human TP53 Polyclonal Antibody, Phospho-Ser6

CPB-655RH 100 ul
EUR 670.8

Rabbit Anti-Human AR Polyclonal Antibody, Phospho-Ser213

CPB-681RH 100 ul
EUR 670.8

Rabbit Anti-Human AR Polyclonal Antibody, Phospho-Ser650

CPB-682RH 100 ul
EUR 670.8

Rabbit Anti-Human CFL1 Polyclonal Antibody, Phospho-Ser3

CPB-698RH 100 ul
EUR 670.8

Histone H3(Phospho-Thr3) Rabbit Polyclonal Polyclonal Conjugated Antibody

C12083 100ul
EUR 476.4

Histone H3(Phospho-Ser10) Rabbit Polyclonal Polyclonal Conjugated Antibody

C12084 100ul
EUR 476.4

Histone H3(Phospho-Thr11) Rabbit Polyclonal Polyclonal Conjugated Antibody

C12085 100ul
EUR 476.4

Histone H3(Phospho-Ser28) Rabbit Polyclonal Polyclonal Conjugated Antibody

C12086 100ul
EUR 476.4

Histone H4(Phospho-Ser1) Rabbit Polyclonal Polyclonal Conjugated Antibody

C12091 100ul
EUR 476.4

Rabbit Anti-Human KIT Polyclonal Antibody, Phospho-Tyr721

CPB-774RH 100 ul
EUR 670.8

Rabbit Anti-Human CDK1 Polyclonal Antibody, Phospho-Tyr15

CPB-776RH 100 ul
EUR 670.8

Rabbit Anti-Human MAPK9 Polyclonal Antibody, Phospho- Thr183

CPB-781RH 100 ul
EUR 670.8

Rabbit Anti-Human NF2 Polyclonal Antibody, Phospho-Ser518

CPB-794RH 100 ul
EUR 670.8

Rabbit Anti-Human KRT8 Polyclonal Antibody, Phospho-Ser74

CPB-823RH 100 ul
EUR 670.8

Rabbit Anti-Human LCK Polyclonal Antibody, Phospho-Tyr505

CPB-858RH 100 ul
EUR 670.8

Rabbit Anti-Human KIT Polyclonal Antibody, Phospho-Tyr936

CPB-860RH 100 ul
EUR 670.8

Rabbit Anti-Human CDK6 Polyclonal Antibody, Phospho-Tyr13

CPB-862RH 100 ul
EUR 670.8

Rabbit Anti-Human CDK6 Polyclonal Antibody, Phospho-Tyr24

CPB-863RH 100 ul
EUR 670.8

Rabbit Anti-Human CBL Polyclonal Antibody, Phospho-Tyr700

CPB-865RH 100 ul
EUR 670.8

Rabbit Anti-Human SKY Polyclonal Antibody, Phospho-Tyr323

CPB-866RH 100 ul
EUR 670.8

Rabbit Anti-Human NBN Polyclonal Antibody, Phospho-Ser343

CPB-628RH 100 ul
EUR 670.8

Rabbit Anti-Human EZR Polyclonal Antibody, Phospho-Tyr353

CPB-631RH 100 ul
EUR 670.8

Rabbit Anti-Human EZR Polyclonal Antibody, Phospho-Tyr353

CPB-632RH 100 ul
EUR 670.8

Rabbit Anti-Human BAD Polyclonal Antibody, Phospho-Ser112

CPB-633RH 100 ul
EUR 670.8

Rabbit Anti-Human BAD Polyclonal Antibody, Phospho-Ser136

CPB-634RH 100 ul
EUR 670.8

Rabbit Anti-Human PGR Polyclonal Antibody, Phospho-Ser190

CPB-639RH 100 ul
EUR 670.8

Rabbit Anti-Human KDR Polyclonal Antibody, Phospho-Tyr951

CPB-651RH 100 ul
EUR 670.8

Rabbit Anti-Human PXN Polyclonal Antibody,Phospho-Tyr118

CPB-653RH 100 ul
EUR 670.8

Rabbit Anti-Human CAV1 Polyclonal Antibody, Phospho-Tyr14

CPB-654RH 100 ul
EUR 670.8

Rabbit Anti-Human TP53 Polyclonal Antibody, Phospho-Ser15

CPB-656RH 100 ul
EUR 670.8

Rabbit Anti-Human TP53 Polyclonal Antibody, Phospho-Thr18

CPB-657RH 100 ul
EUR 670.8

Rabbit Anti-Human TP53 Polyclonal Antibody, Phospho-Ser33

CPB-659RH 100 ul
EUR 670.8

Rabbit Anti-Human TP53 Polyclonal Antibody, Phospho-Ser37

CPB-660RH 100 ul
EUR 670.8

Rabbit Anti-Human TP53 Polyclonal Antibody, Phospho-Ser46

CPB-661RH 100 ul
EUR 670.8

Rabbit Anti-Human PLCG1 Polyclonal Antibody, Phospho- Tyr783

CPB-665RH 100 ul
EUR 670.8

Rabbit Anti-Human GRIN1 Polyclonal Antibody, Phospho- Ser896

CPB-666RH 100 ul
EUR 670.8

Rabbit Anti-Human CHUK Polyclonal Antibody, Phospho-Thr23

CPB-689RH 100 ul
EUR 534

Rabbit Anti-Human RB1 Polyclonal Antibody, Phospho-Ser795

CPB-690RH 100 ul
EUR 534

Rabbit Anti-Human RB1 Polyclonal Antibody, Phospho-Ser807

CPB-691RH 100 ul
EUR 534

Rabbit Anti-Human RB1 Polyclonal Antibody, Phospho-Ser780

CPB-692RH 100 ul
EUR 534

Rabbit Anti-Human LCK Polyclonal Antibody, Phospho-Tyr394

CPB-701HR 100 ul
EUR 670.8

Rabbit Anti-Human SRC Polyclonal Antibody, Phospho-Tyr529

CPB-709RH 100 ul
EUR 670.8

Rabbit Anti-Human Met Polyclonal Antibody, Phospho-Tyr1234

CPB-765RH 100 ul
EUR 670.8

Rabbit Anti-Human EGFR Polyclonal Antibody, Phospho-Tyr869

CPB-767RH 100 ul
EUR 670.8

Rabbit Anti-Human IRS1 Polyclonal Antibody, Phospho-Ser636

CPB-768RH 100 ul
EUR 670.8

Rabbit Anti-Human IRS1 Polyclonal Antibody, Phospho-Ser639

CPB-769RH 100 ul
EUR 670.8

Rabbit Anti-Human RPS6 Polyclonal Antibody, Phospho-Ser235

CPB-770RH 100 ul
EUR 670.8

Rabbit Anti-Human STMN1 Polyclonal Antibody, Phospho-Ser16

CPB-772RH 100 ul
EUR 670.8

Rabbit Anti-Human MET Polyclonal Antibody, Phospho-Tyr1349

CPB-773RH 100 ul
EUR 670.8

Rabbit Anti-Human HSPB1 Polyclonal Antibody, Phospho-Ser78

CPB-779RH 100 ul
EUR 670.8

Rabbit Anti-Human HSPB1 Polyclonal Antibody, Phospho-Ser78

CPB-780RH 100 ul
EUR 670.8

Rabbit Anti-Human RELB Polyclonal Antibody, Phospho-Ser573

CPB-786RH 100 ul
EUR 670.8

Rabbit Anti-Human SNCA Polyclonal Antibody, Phospho-Tyr125

CPB-787RH 100 ul
EUR 670.8

Rabbit Anti-Human MAPT Polyclonal Antibody, Phospho-Thr212

CPB-788RH 100 ul
EUR 670.8

Rabbit Anti-Human GJA1 Polyclonal Antibody, Phospho-Ser367

CPB-789RH 100 ul
EUR 670.8

Rabbit Anti-Human HSF1 Polyclonal Antibody, Phospho-Ser303

CPB-791RH 100 ul
EUR 670.8

Rabbit Anti-Human MAPT Polyclonal Antibody, Phospho-Ser422

CPB-798RH 100 ul
EUR 670.8

Rabbit Anti-Human CTTN Polyclonal Antibody,Phospho-Tyr466

CPB-799RH 100 ul
EUR 670.8

Rabbit Anti-Human DOK1 Polyclonal Antibody, Phospho-Tyr361

CPB-801RH 100 ul
EUR 670.8

Rabbit Anti-Human DOK1 Polyclonal Antibody, Phospho-Tyr398

CPB-802RH 100 ul
EUR 670.8

Rabbit Anti-Human DOK2 Polyclonal Antibody, Phospho-Tyr299

CPB-803RH 100 ul
EUR 670.8

Rabbit Anti-Human EIF2A Polyclonal Antibody, Phospho-Ser51

CPB-804RH 100 ul
EUR 670.8

Rabbit Anti-Human GAP43 Polyclonal Antibody, Phospho-Ser41

CPB-806RH 100 ul
EUR 670.8

Rabbit Anti-Human SNCA Polyclonal Antibody, Phospho-Tyr133

CPB-809RH 100 ul
EUR 670.8

Rabbit Anti-Human SNCA Polyclonal Antibody, Phospho-Tyr136

CPB-810RH 100 ul
EUR 670.8

Rabbit Anti-Human GAB1 Polyclonal Antibody, Phospho-Tyr627

CPB-814RH 100 ul
EUR 670.8

Rabbit Anti-Human KRT18 Polyclonal Antibody, Phospho-Ser33

CPB-822RH 100 ul
EUR 670.8

Rabbit Anti-Human SHC1 Polyclonal Antibody, Phospho-Tyr349

CPB-828RH 100 ul
EUR 670.8

Rabbit Anti-Human SHC1 Polyclonal Antibody, Phospho-Tyr427

CPB-829RH 100 ul
EUR 670.8

Rabbit Anti-Human MDM2 Polyclonal Antibody, Phospho-Ser166

CPB-867RH 100 ul
EUR 670.8

Rabbit Anti-Human SUFU Polyclonal Antibody, Phospho-Ser342

CPB-869RH 100 ul
EUR 670.8

Rabbit Anti-Human IRS1 Polyclonal Antibody, Phospho-Ser312

CPB-1258RH 100 ul
EUR 670.8

Rabbit Anti-Human EIF2S2 Polyclonal Antibody, phospho-Ser2

CPB-1265RH 100 ul
EUR 670.8

Rabbit Anti-Human ATF4 Polyclonal Antibody, Phospho-Ser245

CPB-624RH 100 ul
EUR 670.8

Rabbit Anti-Human AKT1 Polyclonal Antibody, Phospho-Ser473

CPB-625RH 100 ul
EUR 670.8

Rabbit Anti-Human AKT1 Polyclonal Antibody, Phospho-Tyr308

CPB-626RH 100 ul
EUR 670.8

Rabbit Anti-Human PTK2 Polyclonal Antibody, Phospho-Tyr861

CPB-630RH 100 ul
EUR 670.8

Rabbit Anti-Human ESR1 Polyclonal Antibody, Phospho-Ser104

CPB-635RH 100 ul
EUR 670.8

Rabbit Anti-Human ESR1 Polyclonal Antibody, Phospho-Ser106

CPB-636RH 100 ul
EUR 670.8

Rabbit Anti-Human ESR1 Polyclonal Antibody, Phospho-Ser118

CPB-637RH 100 ul
EUR 670.8

Rabbit Anti-Human ESR1 Polyclonal Antibody, Phospho-Ser167

CPB-638RH 100 ul
EUR 670.8

Rabbit Anti-Human ERBB2 Polyclonal Antibody, Phospho- Tyr1248

CPB-644RH 100 ul
EUR 670.8

Rabbit Anti-Human KDR Polyclonal Antibody, Phospho-Tyr1175

CPB-649RH 100 ul
EUR 670.8

Rabbit Anti-Human KDR Polyclonal Antibody, Phospho-Tyr1214

CPB-650RH 100 ul
EUR 670.8

Rabbit Anti-Human TP53 Polyclonal Antibody, Phospho-Ser315

CPB-662RH 100 ul
EUR 670.8

Rabbit Anti-Human MAPT Polyclonal Antibody, Phospho-Ser356

CPB-663RH 100 ul
EUR 670.8

Rabbit Anti-Human MAPT Polyclonal Antibody, Phospho-Ser396

CPB-664RH 100 ul
EUR 670.8

Rabbit Anti-Human MAPT Polyclonal Antibody, Phospho-Ser235

CPB-668RH 100 ul
EUR 670.8

Rabbit Anti-Human MAPT Polyclonal Antibody, Phospho-Thr181

CPB-669RH 100 ul
EUR 670.8

Rabbit Anti-Human MAPT Polyclonal Antibody, Phospho-Thr205

CPB-670RH 100 ul
EUR 670.8

Rabbit Anti-Human MAPT Polyclonal Antibody, Phospho-Ser214

CPB-671RH 100 ul
EUR 670.8

Rabbit Anti-Human MAPT Polyclonal Antibody, Phospho-Thr231

CPB-672RH 100 ul
EUR 670.8

Rabbit Anti-Human MAPT Polyclonal Antibody, Phospho-Ser262

CPB-673RH 100 ul
EUR 670.8

Rabbit Anti-Human MAPT Polyclonal Antibody, Phospho-Ser404

CPB-674RH 100 ul
EUR 670.8

Treatment with leaf extract significantly suppressed the production of inflammatory mediators such as nitric oxide and reactive oxygen species and pro-inflammatory cytokine expression in LPS-stimulated RAW 264.7 cells.

Related Post

Leave A Comment