Incontinence pigmenti is an X-linked genodermatosis generally lethal in males; thus, present almost exclusively in women. It is caused by mutations of loss-of-function in IKBKG (inhibitor of kappa polypeptide enhancer genes in B cells, kinase gamma) gene that prevents the NFкβ (nuclear factor kappa-light-chain-enhancer of B cells activated) protein from migrating into the core to initiate transcription factor that strengthens the body’s immune response and preventing apoptosis.
As a result, the mutant cells become susceptible to apoptosis when exposed to cytokines and, in turn, causes vaso-occlusion and ischemia tissue, such as skin, central nervous system and retina. dermatological lesions are characteristic and occurred in 100% of patients; they are distributed along the lines of Blaschko, which follows the pattern of migration of skin cells in embryogenesis. Skin manifestations follow a sequence of four phases of birth: vesicular, verrucous, hyper- and hypopigmentation. These lesions relevant to this disease because they guide the doctor to diagnosis. In addition, they are accompanied by neurological disorders, such as seizures, and some manifestations of ophthalmology, such as retinal detachment. Incontinence pigmenti patients uncompromised eye drops or clinically significant neurologic prognosis is good and normal life expectancy. This abnormality is permanent, which could be a cause of concern for the patient.
He Incontinence pigmenti es una genodermatosis ligada al cromosoma X, generalmente lethal en los hombres. Está causada por una mutación con Perdida de funcion en el gen IKBKG (inhibitor of kappa polypeptide enhancer genes in B cells kinase gamma), que impide que la protein NFкβ (nuclear factor kappa-light-chain-enhancer of B cells activated) al Migre Nucleo comience y que la transcripción de factores amplifican y la respuesta inmunitaria previenen la apoptosis.
Por tanto, las células Mutantes vuelven vulnerables se cuando la apoptosis child citocinas y provocan expuestas a vaso-oclusión e isquemia de Tejidos como la piel, el sistema nervioso central y la retina. Las lesiones dermatológicas Características child; distribuyen se lo largo de las Líneas de Blaschko, las cuales siguen El Patron de migración de las células de la piel en la embryogenesis, ocurren y en el 100% de los pacientes. Las manifestaciones cutáneas aparecen en una secuencia de cuatro fases inicia que desde el nacimiento: vesicular, verrucosa, hiperpigmentada e hipopigmentada. Estas son lesiones relevantes, orientan al Puesto que hacia el diagnóstico Clinico.
Además, se acompañan de anomalías neurológicas, como convulsivas crisis, oftalmológicas manifestaciones multiples y, como el desprendimiento de la retina. Los pacientes con Incontinence pigmenti, pero sin Compromiso oftalmológico o neurológico clínicamente significativo, Tienen un pronóstico bueno y una esperanza de vida normal. Las anomalías que se presentan permanentes child, lo que puede generar preocupación en los pacientes.
Anti-inflammatory effects of Lasia spinosa Leaf Extract on Lipopolysaccharide-Induced RAW 264.7 macrophages.
Lasia spinosa (L.) Thwaites used as a traditional medicine to treat many inflammatory diseases for centuries. However, its effects on the inflammatory response has not been marked. In this study, we investigated the anti-inflammatory activity of spinosa L. leaf extract in lipopolysaccharide (LPS) -induced RAW 264.7 macrophages. We found that the ethanol extract of the leaves spinosa L. showed anti-oxidant activity because of their high levels of polyphenolic compounds.
Description: This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Phospho-BAD(S32) . This antibody is tested and proven to work in the following applications:
Description: A polyclonal antibody against Phospho-FOS (S32). Recognizes Phospho-FOS (S32) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000
Description: A polyclonal antibody against Phospho-NFKBIA (S32/S36). Recognizes Phospho-NFKBIA (S32/S36) from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000
Description: This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family.
Description: A polyclonal antibody for detection of MRP-S32 from Human. This MRP-S32 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MRP-S32 at AA rangle: 50-130
Description: A polyclonal antibody for detection of MRP-S32 from Human. This MRP-S32 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MRP-S32 at AA rangle: 50-130
Description: A polyclonal antibody for detection of MRP-S32 from Human. This MRP-S32 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MRP-S32 at AA rangle: 50-130
Description: IkappaB‚Äêalpha is a protein encoded by the NFKBIA gene which is approximately 35,6 kDa. IkappaB‚Äêalpha is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, 4-1BB pathway and toll-like receptor signalling pathways. It inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. IkappaB‚Äêalpha is expressed in adherent monocytes. Mutations in the NFKBIA gene may result in ectodermal dysplasia with T-cell immunodeficiency. STJ90311 is a synthesized peptide derived from human IkappaB-alpha around the phosphorylation site of S32/S36. This primary antibody specifically binds to endogenous IkappaB‚Äêalpha protein which only binds about S23/36 when S23/36 is phosphorylated.
HSV-?(Herpes Simplex Virus ?Antibody IgG) ELISA test
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMP3 (aa23-36). This antibody is tested and proven to work in the following applications:
Description: A Rabbit Polyclonal antibody against PRC1(Phospho-Thr481)Rabbit from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA
Description: A Rabbit Polyclonal antibody against PRC1(Phospho-Thr481)Rabbit from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA
Description: A competitive ELISA for quantitative measurement of Rabbit Interleukin 36 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit Interleukin 36 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit Interleukin 36 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Connexin 36 (C-term). This antibody is tested and proven to work in the following applications:
Description: A competitive ELISA for quantitative measurement of Rabbit apelin 36(AP36) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit apelin 36(AP36) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit apelin 36(AP36) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit Interleukin 36 β in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit Interleukin 36 β in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit Interleukin 36 β in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Rabbit Interleukin-36 alpha in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Rabbit Interleukin-36 alpha in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Rabbit Interleukin-36 alpha in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Neuropeptide Y / NPY (aa31-36). This antibody is tested and proven to work in the following applications:
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PPARA / PPAR Alpha (aa22-36). This antibody is tested and proven to work in the following applications:
Treatment with leaf extract significantly suppressed the production of inflammatory mediators such as nitric oxide and reactive oxygen species and pro-inflammatory cytokine expression in LPS-stimulated RAW 264.7 cells.
