SIRT4 suppresses the PI3K/Akt/NF‑κB signaling pathway and attenuates HUVEC injury induced by oxLDL.

Atherosclerosis is a chronic and progressive disease. Its morbidity and mortality have shown an increase in recent years. This study aims to explore the role of sirtuins (SIRT) 4 in the progression of atherosclerosis. Changes in the expression SIRT4 in response to oxidized low density lipoprotein (oxLDL) is measured in human umbilical vein endothelial cells (HUVECs) using western blotting. Cell counting kit-8 and fl ow cytometry tests were used to explore the effects of SIRT4 on HUVEC proliferation and apoptosis.

SIRT4 influence on the expression of inflammatory factors in HUVECs was analyzed using ELISA. Expression and phosphorylation of proteins in the phosphoinositide 3-kinase (PI3K) / protein kinase B (Akt) / nuclear factor (NF) -κB relative paths are analyzed using western blotting. p65 nuclear translocation of NF-kB examined using immunofluorescence. This study showed that treatment decreased the expression SIRT4 oxLDL in HUVECs in a dose-and time-dependent. SIRT4 excess promoted HUVEC oxLDL-induced cell proliferation and apoptosis is inhibited.

Furthermore, excessive SIRT4 suppress the PI3K / Akt / NF-kB pathway by inhibiting the phosphorylation of PI3K and phosphorylated (p) -Akt, p-nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor of α and p-NF-kB p65 expression; blocking NF-kB p65 nuclear translocation and reduced interleukin (IL) -1β, IL-6, and tumor necrosis factor α expression in oxLDL-induced HUVECs. In conclusion, excess SIRT4 enhanced HUVEC survival, suppress the PI3K / Akt / NF-kB signaling pathway and inhibit the inflammatory cytokine expression in oxLDL-induced HUVECs.

SIRT4 suppresses the PI3K/Akt/NF‑κB signaling pathway and attenuates HUVEC injury induced by oxLDL.
SIRT4 suppresses the PI3K/Akt/NF‑κB signaling pathway and attenuates HUVEC injury induced by oxLDL.

Anti-inflammatory effects of aerial bulblets extract of Dioscorea japonica Thunb through inhibition of NF-kB and MAPK signaling pathway in RAW 264.7.

Yam (Dioscorea japonica Thunb) is a well-known health food in Korea and is widely distributed in temperate and tropical regions. Although a variety of health effects from yam has been demonstrated, there is little knowledge about the properties currently Youngyeoja (VCT, the potato crop aerial bulblets), their physiological effects, and their mechanisms action.

To investigate anti-inflammatory effects of VCT, we tested the levels of inflammatory mediators in lipopolysaccharide (LPS) –stimulated RAW 264.7 cells treated with the extract of VCT. Nitric oxide (NO) and prostaglandin E2 levels (PGE2) is determined by using enzyme-linked immunosorbent assay tests. The expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were evaluated by using real-time polymerase chain reaction and western blotting. In addition, activation of nuclear factor-kappaB (NF-kB) and MAPK (MAPK) were detected using western blotting.Treatment real macrophages with LPS-induced production of NO and PGE2.

p38 Antibody

48644-50ul 50ul
EUR 286.8

p38 Antibody

35478-100ul 100ul
EUR 468

p38 Antibody

20-abx141038
  • EUR 427.20
  • EUR 644.40
  • EUR 260.40
  • 100 ul
  • 200 ul
  • 30 ul

p38 Antibody

20-abx133223
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

p38 Antibody

20-abx007541
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

p38 Antibody

abx236076-100ug 100 ug
EUR 577.2

p38 protein

E20-80078 20ug
EUR 489.6

p38 protein

E20-80079 20ug
EUR 489.6

anti-p38

YF-PA23519 50 ul
EUR 400.8
Description: Mouse polyclonal to p38

anti-p38

YF-PA23520 50 ul
EUR 400.8
Description: Mouse polyclonal to p38

anti-p38

YF-PA23521 50 ul
EUR 400.8
Description: Mouse polyclonal to p38

anti-p38

YF-PA11120 50 ug
EUR 435.6
Description: Mouse polyclonal to p38

anti-p38

YF-PA11121 100 ug
EUR 483.6
Description: Rabbit polyclonal to p38

PM 102

B5517-1 1 mg
EUR 721.2

MM-102

B1582-2 2 mg
EUR 153.6
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B1582-20 20 mg
EUR 711.6
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B1582-5 5 mg
EUR 254.4
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B2364-25
EUR 705.6

MM-102

B2364-5
EUR 222

PPQ-102

B3504-10 10 mg
EUR 290.4

PPQ-102

B3504-5 5 mg
EUR 181.2

PPQ-102

B3504-50 50 mg
EUR 1035.6

PPQ-102

HY-14179 100mg
EUR 1465.2

BGB-102

HY-15732 10mg
EUR 7249.2

EL-102

HY-16187 10mM/1mL
EUR 451.2

LSZ-102

HY-111486 50mg
EUR 3985.2

MM-102

HY-12220 10mg
EUR 357.6

IAXO-102

HY-125171 50mg
EUR 2332.8

5(6)-FAM [5-(and-6)-Carboxyfluorescein] *CAS 72088-94-9*

102 25 g
EUR 1051.2

SB-203580 p38 MAPK(p38 MAP kinase) Inhibitor

E1B1863 1mg
EUR 193.2

p38 MAPK antibody

10R-8422 100 ul
EUR 471.6
Description: Mouse monoclonal p38 MAPK antibody

P38 MAPK antibody

70R-34325 100 ug
EUR 392.4
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody

70R-34327 100 ug
EUR 392.4
Description: Rabbit polyclonal P38 MAPK antibody

p38 MAPK antibody

70R-33398 100 ug
EUR 392.4
Description: Rabbit polyclonal p38 MAPK antibody

p38 MAPK antibody

70R-33400 100 ug
EUR 392.4
Description: Rabbit polyclonal p38 MAPK antibody

P38 delta protein

30R-2868 5 ug
EUR 603.6
Description: Purified recombinant Human P38 delta protein

p38 alpha protein

30R-2870 5 ug
EUR 603.6
Description: Purified recombinant Human p38 alpha protein

p38 beta protein

30R-2875 5 ug
EUR 603.6
Description: Purified recombinant Human p38 beta protein

p38 Polyclonal Antibody

41305-100ul 100ul
EUR 302.4

p38 Polyclonal Antibody

41305-50ul 50ul
EUR 224.4

p38 Polyclonal Antibody

41306-100ul 100ul
EUR 302.4

p38 Polyclonal Antibody

41306-50ul 50ul
EUR 224.4

p38 MAPK Antibody

49379-100ul 100ul
EUR 399.6

p38 MAPK Antibody

49379-50ul 50ul
EUR 286.8

p38 MAPK antibody

20R-2950 100 ul
EUR 471.6
Description: Rabbit polyclonal p38 MAPK antibody

p38 MAPK antibody

20R-1572 100 ug
EUR 846
Description: Rabbit polyclonal p38 MAPK antibody

P38 MAPK antibody

20R-2087 50 ug
EUR 337.2
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody

20R-2088 50 ug
EUR 337.2
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody

20R-2403 50 ug
EUR 337.2
Description: Rabbit polyclonal P38 MAPK antibody

p38 (pY323) Antibody

20-abx133058
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

p38 (pY182) Antibody

20-abx134951
  • EUR 460.80
  • EUR 727.20
  • EUR 276.00
  • 100 ul
  • 200 ul
  • 30 ul

p38 Blocking Peptide

20-abx161932
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

p38 Polyclonal Antibody

ABP52112-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52112-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52112-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52113-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP52113-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP52113-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP53838-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53838-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53838-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53839-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody

ABP53839-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody

ABP53839-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody

ABP57354-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody

ABP57354-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody

ABP57354-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Blocking Peptide

20-abx061736
  • EUR 309.60
  • EUR 460.80
  • 1 mg
  • 5 mg

p38 Blocking Peptide

20-abx062080
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

p38 (pT180) Antibody

20-abx009863
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

p38 MAPK Antibody

20-abx012798
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

p38 MAPK Antibody

20-abx012875
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

p38 MAPK Antibody

ABF6456 100 ug
EUR 525.6

p38 MAPK Antibody

abx236077-100ug 100 ug
EUR 577.2

p38 beta, Active

7763-100
EUR 5214

p38 beta, Active

7763-5
EUR 444

Anti-p38 Antibody

A00176 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for p38 Antibody (MAPK14) detection.tested for WB in Human, Mouse, Rat.

Anti-p38 alpha

DB-1039 100 tests
EUR 568.8

Anti-p38 beta

DB-1040 100 tests
EUR 568.8

Anti-p38 gamma

DB-1041 100 tests
EUR 568.8

Anti-p38 delta

DB-1042 100 tests
EUR 568.8

Anti-p38-a

DB-161-0.05 50 μl
EUR 322.8

Anti-p38-a

DB-161-0.1 100 μl
EUR 506.4

Anti-p38-b

DB-162-0.05 50 μl
EUR 322.8

Anti-p38-b

DB-162-0.1 100 μl
EUR 506.4

Anti-p38-g

DB-163-0.05 50 μl
EUR 322.8

Anti-p38-g

DB-163-0.1 100 μl
EUR 506.4

Anti-p38-d

DB-164-0.05 50 μl
EUR 322.8

Anti-p38-d

DB-164-0.1 100 μl
EUR 506.4

Anti-p38 alpha

DB1039 100 tests
EUR 568.8

Anti-p38 beta

DB1040 100 tests
EUR 568.8

Anti-p38 gamma

DB1041 100 tests
EUR 568.8

Anti-p38 delta

DB1042 100 tests
EUR 568.8

AIMP2/p38 Antibody

DF12048 200ul
EUR 420

Crk p38 Antibody

AF6323 200ul
EUR 420

p38 MAPK Antibody

AF6455 200ul
EUR 420

p38 MAPK Antibody

AF6456 200ul
EUR 420

p38 MAPK Antibody

AF6457 200ul
EUR 420

p38 Polyclonal Antibody

ES3111-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES3111-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES3112-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES3112-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES4837-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES4837-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES4838-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES4838-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Anti-p38 antibody

PAab06076 100 ug
EUR 426

anti-p38 MAPK

LF-PA0160 100 ul
EUR 400.8
Description: Rabbit polyclonal to p38 MAPK

anti- p38 antibody

FNab06076 100µg
EUR 606.3
Description: Antibody raised against p38

p38 Polyclonal Antibody

ES8347-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA

p38 Polyclonal Antibody

ES8347-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA

Anti-p38 antibody

STJ94876 200 µl
EUR 236.4
Description: Rabbit polyclonal to p38.

Anti-p38 antibody

STJ94877 200 µl
EUR 236.4
Description: Rabbit polyclonal to p38.

Anti-p38 antibody

STJ94878 200 µl
EUR 236.4
Description: p38 is a protein encoded by the MAPK14 gene which is approximately 41,2 kDa. p38 is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, the IL-2 pathway, toll-like receptor signalling pathways, the VEGF signalling pathway and 4-1BB pathway. This protein falls under the MAP kinase family. It acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. p38 is expressed in the brain, heart, placenta, pancreas and skeletal muscle. Mutations in the MAPK14 gene may result in patellar tendinitis and lumbosacral lipoma. STJ94878 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of p38 protein.

Anti-p38 antibody

STJ94879 200 µl
EUR 236.4
Description: Rabbit polyclonal to p38.

Anti-P38 antibody

STJ98898 200 µl
EUR 236.4
Description: Mouse monoclonal to P38.

Anti-P38 antibody

STJ98899 200 µl
EUR 236.4
Description: Mouse monoclonal to P38.

Anti-p38 antibody

STJ97615 200 µl
EUR 236.4
Description: Rabbit polyclonal to p38.

p38 alpha-MAPK14

RA15053 100 ug
EUR 631.2

Anti-p38 (3D5)

YF-MA12551 200 ul
EUR 435.6
Description: Mouse monoclonal to p38

Anti-p38 (1C9)

YF-MA12552 100 ug
EUR 435.6
Description: Mouse monoclonal to p38

anti-Crk p38

YF-PA23509 50 ul
EUR 400.8
Description: Mouse polyclonal to Crk p38

anti-Crk p38

YF-PA11088 50 ul
EUR 435.6
Description: Mouse polyclonal to Crk p38

anti-Crk p38

YF-PA11089 50 ug
EUR 435.6
Description: Mouse polyclonal to Crk p38

anti-Crk p38

YF-PA11090 100 ug
EUR 483.6
Description: Rabbit polyclonal to Crk p38

anti-AIMP2/p38

YF-PA15507 50 ug
EUR 435.6
Description: Mouse polyclonal to AIMP2/p38

BP-1-102

HY-100493 100mg
EUR 1614

MM-102 (TFA)

HY-12220A 10mM/1mL
EUR 315.6

Mouse P38 Mitogen-activated Protein Kinase (MAPK P38) CLIA Kit

abx197397-96tests 96 tests
EUR 990

Mouse MAPK P38(P38 Mitogen-activated Protein Kinase) ELISA Kit

EM1199 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.75 ng/ml

p38 MAP Kinase antibody

70R-11620 100 ug
EUR 501.6
Description: Rabbit polyclonal p38 MAP Kinase antibody

Phospho-p38 MAPK antibody

70R-11824 100 ug
EUR 630
Description: Rabbit polyclonal Phospho-p38 MAPK antibody

p38 MAPK Rabbit pAb

A10832-100ul 100 ul
EUR 460.8

p38 MAPK Rabbit pAb

A10832-200ul 200 ul
EUR 664.8

p38 MAPK Rabbit pAb

A10832-20ul 20 ul
EUR 219.6

p38 MAPK Rabbit pAb

A10832-50ul 50 ul
EUR 318

p38 MAPK Rabbit pAb

A14401-100ul 100 ul
EUR 369.6

YYJ treatment of inflammatory mediators and inhibit the induction of the expression of iNOS and COX-2. phosphorylation, more importantly, LPS-induced nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor (IκB) was suppressed by treatment with the VFA, VFA showed inhibit the activation of NF-kB. Furthermore, VFA inhibits LPS-induced phosphorylation MAPKs.YYJ shown to have potent anti-inflammatory effects in LPS-stimulated RAW 264.7 cells, which can be attributed to an inhibitory effect on NF-kB and MAPK activation, consequently blocking the production of inflammatory factors. Therefore, these results indicate that extracts of VCT can be used as an anti-inflammatory agent.