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Synthesis and Characterization of the Novel N ε-9-Fluorenylmethoxycarbonyl-l-Lysine N-Carboxy Anhydride. Synthesis of Well-Defined Linear and Branched Polypeptides

Synthesis and Characterization of the Novel N ε-9-Fluorenylmethoxycarbonyl-l-Lysine N-Carboxy Anhydride. Synthesis of Well-Defined Linear and Branched Polypeptides
Posted by Anna

The synthesis of well-defined polypeptides show complex macromolecular architecture requires the use of monomers that can be grouped by orthogonally grouped, containing primary amines that will be used as initiary for polymerization of the ring opening (ROP) anhydride n-carboxy. Synthesis and characterization of novel nε-9-fluorylmethoxycarbony-ls-carboxy anhydride (Na-FMOC-Lysine NCA), as well as linear poly novel (Nε-FMOC-L-Lys) n homopipeptide and poly (L-lysine) 78- Block- [Poly (L-Lysine) 10-graft-poly (L-Histidine) 15] Copolypeptide block-graft, served.

The copolypeptide graft synthesis was carried out through the NA-BOC-L-Lysine NCA ROP when using n-hexylamine as an initiator, followed by the polymerization of NCA Nε-FMOC-L-lysine. The latest blocks are selectively explored in basic conditions, and the resulting ε-amine is used as an initiation species for ROP NIM-Trity-L-Histidine NCA. Finally, the Board of Commissioners and Trt groups were sentenced by TFA. High vacuum techniques are applied to achieve the conditions needed for well-defined polypeptide synthesis. Molecular characterization shows that polypeptides show molecular homogeneity and high composition.

Finally, dynamic light scattering, ζ-potential, and a circular crocated measurement is used to investigate the ability of polypeptides to gather itself in different conditions. This monomer paves the way for polypeptide synthesis with complex macromolecular architecture that can define aggregation behavior, and, therefore, can cause the synthesis of responsive nanocarrier “smart” stimulation for controlled drug delivery applications.

Antimicrobial multifunctional polypeptide-selenium nanoparticles combating drug resistance bacteria

Antibiotic-resistant bacteria are severe threats to human health. The global global surveillance system of the Health Health Health has revealed antibiotic resistance between half a million patients in 22 countries, with Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae became the most resistant species. Antimicrobial nanoparticles emerged as an alternative that promised antibiotics in the fight against antimicrobial resistance. In this work, selenium nanoparticles are coated with antimicrobial polypeptides, ε-poly-licin, (SE np-ε-pl) synthesized and antibacterial activity and cytotoxicity investigated. SE NP-ε-PL which shows significantly larger antibacterial activity of all eight species of bacteria tested, including gram-positive, gram-negative strains, and drug resistance, than their individual components, SE NP and ε-pl.

Nanoparticles do not show toxicity to human dermal fibroblasts at the minimum inhibitory concentration, showing therapeutic windows. Furthermore, unlike conventional kanamycin antibiotics, SE NP-ε-PL does not easily induce resistance to E. coli or S. aureus. In particular, S. aureus began developing resistance to Kanamycin from the generation of ~ 44, while needed ~ 132 generations for resistance to develop into SE np-ε-pl. Surprisingly, E. coli cannot develop resistance to nanoparticles above ~ 300 generations. These results indicate that the multifunctional approach to combining SE NP with ε-PL to form SE NP-ε-PL is a new strategy that is very efficacious with the antibacterial activity of the width spectrum, low cytotoxicity, and significant delay in the development of resistance.

Open polypeptides open surface are successfully used as targets to develop a one-step prototype immunochromatography strip for specific and sensitive direct detection of staphylococcus aureus which causes neonatal sepsis

Neonatal sepsis is a life-threatening condition and Staphylococcus aureus is one of the main causes. However, until now, there are no fast and sensitive diagnostic tools have been developed for direct detection. Bioinformatics analysis identifies 112 amino acid polypeptides exposed to the surface of the cell protein nwmn_1649 cell walls, surface protein involved in cell aggregation and biofilm formation, as specific species and moiety which is highly preserved.

Synthesis and Characterization of the Novel N ε-9-Fluorenylmethoxycarbonyl-l-Lysine N-Carboxy Anhydride. Synthesis of Well-Defined Linear and Branched Polypeptides

Polypeptides are cloned, purified, and used to immunize mice to increase certain immunoglobulin. Purified antibodies are conjugated to gold nano particles and are used to assemble immunochromatographic strips (ICS). The prototype IC developed is detected as low as 5 μg of pure polypeptides and 102 CFU / ML S. aureus in 15 minutes. The strip shows superior ability to directly detect S. aureus in the blood specimens of neonatal sepsis without previous sample processing. In addition, it does not show cross reactions in specimens infected with two other main causes of neonatal sepsis; Koagulase-negative Staphylococci and Klebsiella pneumoniae. The selected NWMN_1649 polypeptide shown shows success as a promising biomolecule where IC prototypes have been developed. This ICS provides fast, direct, sensitive and specific options for S. aureus detection which causes neonatal sepsis. Such tools are needed especially in limited countries of resources.

Stabilization of oil emulsion in soybean water using multilayers polypeptides: cationic polylysine and anionic acid polyglutamate

Oil-in-water emulsions are used as a shipping system for non-polar functional materials in various industries, including food, cosmetics, personal care products, agrochemicals and pharmaceuticals. However, emulsions tend to be damaged in conditions found in many commercial products. In this study, the functional performance of lipid droplets in emulsions is adjusted to electrostatic deposition of layers after the sequential layers of charged polypeptides contrary to their surface. Cationic Poly-L-lysine (PLL) and anionic poly-glutamic acid (PGA) are used as a pair of polypeptides imposed on the opposite (pH 4.0).

First, the primary emulsion (10% W / W soybean oil emulsion) is formed consisting of small lipid droplets (D32 = 500 μm) coated by natural surfactants (0.05% w / w Quilleta Saponin). Second, Cationic PLL is saved to the surface of anionic saponin-plated droplets. Third, Anionic PGA was saved to the surface of the cationic PLL-Saponin-plated droplets. We then assess the ability of coatings to protect lipid droplets from aggregation when pH (2.0-9.0), ionic power (0-350 mm), or temperature (30-90 ° C) changed. Primary, secondary and tertiary emulsion properties are monitored by measuring the average particle diameter (D32), electrical characteristics (ζ-potential), and micro from lipid droplets.

TAT Peptide

abx266559-1ml 1 ml
EUR 287.5

TAT Peptide

abx266559-200l 200 µl
EUR 237.5

TAT peptide

TP1451-10mg 10mg Ask for price
Description: TAT peptide

TAT peptide

TP1451-1g 1g Ask for price
Description: TAT peptide

TAT peptide

TP1451-1mg 1mg Ask for price
Description: TAT peptide

TAT peptide

TP1451-50mg 50mg Ask for price
Description: TAT peptide

TAT peptide

TP1451-5mg 5mg Ask for price
Description: TAT peptide

TAT peptide

MBS5763704-10mg 10mg
EUR 765

TAT peptide

MBS5763704-1mg 1mg
EUR 190

TAT peptide

MBS5763704-5mg 5mg
EUR 485

TAT peptide

MBS5763704-5x10mg 5x10mg
EUR 3305

Peptide E / 3200-Dalton Adrenal Enkephalin-Containing Peptide (Bovine)

024-57 200 μg
EUR 86.4

PSTAIR Peptide

070-61 500 μg
EUR 129.6

PGMtide Peptide

040-69 100 μg
EUR 316.44

Adjuvant Peptide

070-05 500 μg
EUR 36.72


058-22 500 μg
EUR 114.48

Delicious Peptide

070-21 5 mg
EUR 160.92

proSex peptide (20-55)

040-30 100 μg
EUR 355.32

proSex peptide (28-55)

040-31 100 μg
EUR 282.96

proSex peptide (40-55)

040-32 100 μg
EUR 214.92

Bombinin-Like Peptide 1 amide / prepro-Bombinin-Like Peptide (44-70) amide / prepro-Bombinin-Like Peptide (107-133) amide

007-60 100 μg
EUR 214.92

Peptide F-9

038-06 200 μg
EUR 58.32

Sturgeon Peptide (137-158)

021-94 100 μg
EUR 177.12

Peptide Lv (Rat)

008-73 100 μg
EUR 469.8

NGR Peptide 1

025-74 200 μg
EUR 184.68

Anorexigenic Peptide

070-10 5 mg
EUR 86.4

GnRH Associated Peptide (GAP) (1-13) / GnRH Precursor Peptide (14-26) (Human)

029-03 500 μg
EUR 114.48

GnRH Associated Peptide (GAP) (1-24) / GnRH Precursor Peptide (14-37) (Human)

029-04 100 μg
EUR 114.48

GnRH Associated Peptide (GAP) (1-53) / GnRH Precursor Peptide (14-66) (Human)

029-05 20 μg
EUR 267.84

GnRH Associated Peptide (GAP) (25-53) / GnRH Precursor Peptide (38-66) (Human)

029-06 100 μg
EUR 114.48

Bid BH3 peptide

025-87 1 mg
EUR 170.64

AF-16 Peptide

033-44 200 μg
EUR 214.92

Peptide Lv (Human)

008-71 100 μg
EUR 405

Peptide Lv (Mouse)

008-72 100 μg
EUR 469.8

GnRH Associated Peptide (GAP) (1-13) / Gn-RH Precursor Peptide (14-26) (Rat)

029-08 200 μg
EUR 64.8

Peptide B (Bovine)

024-56 200 μg
EUR 81

Peptide F (Bovine)

024-58 200 μg
EUR 114.48

ExE peptide M3mP6

064-33 200 μg
EUR 244.08

PLP Peptide (103-116) (Bovine)

070-14 5 mg
EUR 140.4

FMRF-Like Peptide

047-32 1 mg
EUR 27

Joining Peptide (Rat)

047-91 200 μg
EUR 160.92

Growth Hormone-Releasing Peptide-Related Peptide-1 (fGRP-RP-1) (Frog)

048-80 500 μg
EUR 177.12

Growth Hormone-Releasing Peptide-Related Peptide-2 (fGRP-RP-2) (Frog)

048-81 200 μg
EUR 214.92

Growth Hormone-Releasing Peptide-Related Peptide-3 (fGRP-RP-3) (Frog)

048-82 200 μg
EUR 214.92

Peptide T (4-8)

057-04 500 μg
EUR 64.8

Peptide T (5-8)

057-05 500 μg
EUR 64.8

Vasonatrin Peptide (VNP)

005-47 200 μg
EUR 214.92

Opioid Peptide Library

L-002 58 peptides
EUR 2691.36

Peptide Histidine Isoleucine 27 (PHI-27) / Porcine Intestinal Peptide (Porcine)

064-01 200 μg
EUR 108

Heparin Binding Peptide

025-47 500 μg
EUR 102.6

Gastrin Related Peptide

027-09 5 mg
EUR 73.44

PGMtide Control Peptide

040-70 100 μg
EUR 316.44

Growth Blocking Peptide

046-92 100 μg
EUR 255.96

Neuron Specific Peptide

047-55 200 μg
EUR 140.4

Obesity Peptide Library

L-003 160 peptides
EUR 7267.32

[D-Ala1]-Peptide T

057-02 5 mg
EUR 282.96

Peptide YY (PYY) (Human)

059-01 200 μg
EUR 119.88

Eledoisin Related Peptide

046-04 5 mg
EUR 58.32

proSex peptide (28-55) - EIA Kit

EK-040-31 96 wells
EUR 603.72

Peptide F 1 (Lobster)

047-62 500 μg
EUR 73.44

Morphine Tolerance Peptide

050-13 1 mg
EUR 102.6

Phosphate Acceptor Peptide

058-24 500 μg
EUR 73.44

Peptide Histidine Methionine 27 (PHM-27) / Peptide Histidine Isoleucine (PHI) (Human)

064-07 200 μg
EUR 114.48

Peptide I / pro-Histine-Rich Basic Peptide (HRBP) (1-26) (Aplysia brasiliana)

047-39 200 μg
EUR 444.96

Peptide II / pro-Histine-Rich Basic Peptide (HRBP) (29-40) (Aplysia brasiliana)

047-40 500 μg
EUR 214.92

Peptide I / pro-Histine-Rich Basic Peptide (HRBP) (1-26) (Aplysia californica)

047-42 200 μg
EUR 444.96

Peptide II / pro-Histine-Rich Basic Peptide (HRBP) (29-40) (Aplysia californica)

047-43 500 μg
EUR 214.92

FGL Peptide - Cy3 Labeled

FC3-073-36 1 nmol
EUR 672.84

FGL Peptide - Cy5 Labeled

FC5-073-36 1 nmol
EUR 756

FGL Peptide - FAM Labeled

FG-073-36A 1 nmol
EUR 405

Pedal Peptide (Pep) (Aplysia)

047-61 500 μg
EUR 177.12

ExE peptide M3mP6 mutant

064-35 200ug
EUR 234.36

ExE peptide M3mP6 mutant

064-37 200ug
EUR 234.36

FGL Peptide - FITC Labeled

FG-073-36B 1 nmol
EUR 405

AF-16 Peptide - Antibody

H-033-44 100 μl
EUR 336.96

Schizophrenia Related Peptide

047-79 5 mg
EUR 44.28

Insulin B (22-25) Peptide

035-08 5 mg
EUR 86.4

Eosinophilotactic Peptide (AGSE)

070-28 5 mg
EUR 27

Eosinophilotactic Peptide (VGSE)

070-29 5 mg
EUR 27

Cell Penetrating ARF Peptide (26-44)

068-56 500 μg
EUR 640.44

Peptide Histidine Isoleucine 27 (PHI-27) / Porcine Intestinal Peptide (Porcine) - RIA Kit

RK-064-01 125 tubes
EUR 932.04

FGL Peptide - Biotin Labeled

B-073-36 20 μg
EUR 405

Peptide F (Bovine) - Antibody

H-024-58 50 μl
EUR 238.68

Brain Peptide (Bees) Library

L-007 51 peptides
EUR 6456.24

TAT Derivative, R9-Tat

068-27 500 μg
EUR 370.44

Gastrointestinal Peptide Library

L-006 200 peptides
EUR 7267.32

[D-Arg14, D-Arg15]-MGF Peptide amide / C-terminal peptide of IGF-1 Ec amide

033-34 100 μg
EUR 177.12

Peptide R / CXCR4 Antagonist

030-25 200 μg
EUR 203.04

PGMtide Peptide - Cy3 Labeled

FC3-040-69 1 nmol
EUR 925.56

PGMtide Peptide - FAM Labeled

FG-040-69A 5 nmol
EUR 537.84

Peptide Histidine Methionine 27 (PHM-27) / Peptide Histidine Isoleucine (PHI) (Human) - Antibody

H-064-07 50 μl
EUR 238.68

[D-Ala1]-Peptide T amide

057-03 500 μg
EUR 140.4

Peptide F (Bovine) - RIA Kit

RK-024-58 125 tubes
EUR 932.04

Peptide Histidine Methionine 27 (PHM-27) / Peptide Histidine Isoleucine (PHI) (Human) - RIA Kit

RK-064-07 125 tubes
EUR 932.04

Catch-Relaxing Peptide (CARP)

047-20 1 mg
EUR 199.8

Calmodulin Binding Peptide 1

070-17 20 μg
EUR 214.92

FGL Peptide - Rhodamine Labeled

FR-073-36 1 nmol
EUR 537.84

Peptide-Depleted Plasma (Rat)

MB-099-02 2 ml
EUR 119.88

Glycogenolysis-Inhibiting Peptide

023-63 500 μg
EUR 177.12

Anti-Inflammatory Peptide 1

004-01 200 μg
EUR 27

Anti-Inflammatory Peptide 2

004-02 200 μg
EUR 27

Anti-Inflammatory Peptide 3

004-03 200 μg
EUR 27

Urokinase-Derived Peptide A6

025-12 500 μg
EUR 129.6

PGMtide Peptide - Biotin Labeled

B-040-69 20 μg
EUR 537.84

Peptide 34 / GPR-54 Agonist

048-94 200 μg
EUR 114.48

FGL Peptide - I-125 Labeled

T-073-36 10 μCi
EUR 1145.88

Peptide Histidine Methionine 27 (PHM-27) / Peptide Histidine Isoleucine (PHI) (Human) - FAM Labeled

FG-064-07A 1 nmol
EUR 336.96

Peptide Histidine Isoleucine 27 (PHI-27) / Porcine Intestinal Peptide (Porcine) - I-125 Labeled

T-064-01 10 μCi
EUR 1145.88

Peptide-Depleted Plasma (Human)

MB-099-01 2 ml
EUR 119.88

F3 Peptide / HMGN2 Fragment 3

004-12 100 μg
EUR 214.92

Antimicrobial Trp-rich peptide

004-05 100 μg
EUR 140.4

Fibronectin CS1 Peptide (EILDVPST)

025-20 500 μg
EUR 86.4

Myosin Kinase Inhibiting Peptide

058-20 500 μg
EUR 50.76

Peptide YY (PYY) (3-36) (Human)

059-02 200 μg
EUR 102.6

PGMtide Peptide - Rhodamine Labeled

FR-040-69 5 nmol
EUR 604.8

Anti-Angiogenic Peptide Library

L-008A 88 peptides
EUR 6067.44

Peptide YY (PYY) (Human) - Antibody

H-059-01 100 μl
EUR 469.8

Peptide Histidine Isoleucine 27 (PHI-27) / Porcine Intestinal Peptide (Porcine) - Purified IgG Antibody

G-064-01 400 μg
EUR 438.48

Peptide A / p60v-src (137-157)

058-21 500 μg
EUR 135

pro-Opionmelanocortin / J Peptide

022-22 200 μg
EUR 177.12

Cancer-Targeting Peptide Library

L-015 289 peptides
EUR 7253.28

C28 optimized peptide 6 (Human)

073-82 100 μg
EUR 235.44

The electrical characteristics of droplets can be modulated by controlling the number and type of layer used. Primary emulsions have the best resistance to various environmental conditions, while secondary emulsions have the worst, suggest electrostatic deposits may only be used to get certain functions. Interestingly, PLL regardless of the surface of the secondary emulsion at high salt concentrations due to electrostatic screening, which increases their salt stability. This phenomenon may be useful for several food applications, eg, have cationic droplets during food storage, but are anionic in the human body.

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