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Synthesis and Characterization of the Novel N ε-9-Fluorenylmethoxycarbonyl-l-Lysine N-Carboxy Anhydride. Synthesis of Well-Defined Linear and Branched Polypeptides

Synthesis and Characterization of the Novel N ε-9-Fluorenylmethoxycarbonyl-l-Lysine N-Carboxy Anhydride. Synthesis of Well-Defined Linear and Branched Polypeptides
Posted by Anna

The synthesis of well-defined polypeptides show complex macromolecular architecture requires the use of monomers that can be grouped by orthogonally grouped, containing primary amines that will be used as initiary for polymerization of the ring opening (ROP) anhydride n-carboxy. Synthesis and characterization of novel nε-9-fluorylmethoxycarbony-ls-carboxy anhydride (Na-FMOC-Lysine NCA), as well as linear poly novel (Nε-FMOC-L-Lys) n homopipeptide and poly (L-lysine) 78- Block- [Poly (L-Lysine) 10-graft-poly (L-Histidine) 15] Copolypeptide block-graft, served.

The copolypeptide graft synthesis was carried out through the NA-BOC-L-Lysine NCA ROP when using n-hexylamine as an initiator, followed by the polymerization of NCA Nε-FMOC-L-lysine. The latest blocks are selectively explored in basic conditions, and the resulting ε-amine is used as an initiation species for ROP NIM-Trity-L-Histidine NCA. Finally, the Board of Commissioners and Trt groups were sentenced by TFA. High vacuum techniques are applied to achieve the conditions needed for well-defined polypeptide synthesis. Molecular characterization shows that polypeptides show molecular homogeneity and high composition.

Finally, dynamic light scattering, ζ-potential, and a circular crocated measurement is used to investigate the ability of polypeptides to gather itself in different conditions. This monomer paves the way for polypeptide synthesis with complex macromolecular architecture that can define aggregation behavior, and, therefore, can cause the synthesis of responsive nanocarrier “smart” stimulation for controlled drug delivery applications.

Antimicrobial multifunctional polypeptide-selenium nanoparticles combating drug resistance bacteria

Antibiotic-resistant bacteria are severe threats to human health. The global global surveillance system of the Health Health Health has revealed antibiotic resistance between half a million patients in 22 countries, with Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae became the most resistant species. Antimicrobial nanoparticles emerged as an alternative that promised antibiotics in the fight against antimicrobial resistance. In this work, selenium nanoparticles are coated with antimicrobial polypeptides, ε-poly-licin, (SE np-ε-pl) synthesized and antibacterial activity and cytotoxicity investigated. SE NP-ε-PL which shows significantly larger antibacterial activity of all eight species of bacteria tested, including gram-positive, gram-negative strains, and drug resistance, than their individual components, SE NP and ε-pl.

Nanoparticles do not show toxicity to human dermal fibroblasts at the minimum inhibitory concentration, showing therapeutic windows. Furthermore, unlike conventional kanamycin antibiotics, SE NP-ε-PL does not easily induce resistance to E. coli or S. aureus. In particular, S. aureus began developing resistance to Kanamycin from the generation of ~ 44, while needed ~ 132 generations for resistance to develop into SE np-ε-pl. Surprisingly, E. coli cannot develop resistance to nanoparticles above ~ 300 generations. These results indicate that the multifunctional approach to combining SE NP with ε-PL to form SE NP-ε-PL is a new strategy that is very efficacious with the antibacterial activity of the width spectrum, low cytotoxicity, and significant delay in the development of resistance.

Open polypeptides open surface are successfully used as targets to develop a one-step prototype immunochromatography strip for specific and sensitive direct detection of staphylococcus aureus which causes neonatal sepsis

Neonatal sepsis is a life-threatening condition and Staphylococcus aureus is one of the main causes. However, until now, there are no fast and sensitive diagnostic tools have been developed for direct detection. Bioinformatics analysis identifies 112 amino acid polypeptides exposed to the surface of the cell protein nwmn_1649 cell walls, surface protein involved in cell aggregation and biofilm formation, as specific species and moiety which is highly preserved.

Synthesis and Characterization of the Novel N ε-9-Fluorenylmethoxycarbonyl-l-Lysine N-Carboxy Anhydride. Synthesis of Well-Defined Linear and Branched Polypeptides

Polypeptides are cloned, purified, and used to immunize mice to increase certain immunoglobulin. Purified antibodies are conjugated to gold nano particles and are used to assemble immunochromatographic strips (ICS). The prototype IC developed is detected as low as 5 μg of pure polypeptides and 102 CFU / ML S. aureus in 15 minutes. The strip shows superior ability to directly detect S. aureus in the blood specimens of neonatal sepsis without previous sample processing. In addition, it does not show cross reactions in specimens infected with two other main causes of neonatal sepsis; Koagulase-negative Staphylococci and Klebsiella pneumoniae. The selected NWMN_1649 polypeptide shown shows success as a promising biomolecule where IC prototypes have been developed. This ICS provides fast, direct, sensitive and specific options for S. aureus detection which causes neonatal sepsis. Such tools are needed especially in limited countries of resources.

Stabilization of oil emulsion in soybean water using multilayers polypeptides: cationic polylysine and anionic acid polyglutamate

Oil-in-water emulsions are used as a shipping system for non-polar functional materials in various industries, including food, cosmetics, personal care products, agrochemicals and pharmaceuticals. However, emulsions tend to be damaged in conditions found in many commercial products. In this study, the functional performance of lipid droplets in emulsions is adjusted to electrostatic deposition of layers after the sequential layers of charged polypeptides contrary to their surface. Cationic Poly-L-lysine (PLL) and anionic poly-glutamic acid (PGA) are used as a pair of polypeptides imposed on the opposite (pH 4.0).

First, the primary emulsion (10% W / W soybean oil emulsion) is formed consisting of small lipid droplets (D32 = 500 μm) coated by natural surfactants (0.05% w / w Quilleta Saponin). Second, Cationic PLL is saved to the surface of anionic saponin-plated droplets. Third, Anionic PGA was saved to the surface of the cationic PLL-Saponin-plated droplets. We then assess the ability of coatings to protect lipid droplets from aggregation when pH (2.0-9.0), ionic power (0-350 mm), or temperature (30-90 ° C) changed. Primary, secondary and tertiary emulsion properties are monitored by measuring the average particle diameter (D32), electrical characteristics (ζ-potential), and micro from lipid droplets.

TAT Antibody

1-CSB-PA050213
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TAT. Recognizes TAT from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000

TAT Antibody

1-CSB-PA023175LA01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TAT. Recognizes TAT from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200

TAT Antibody

1-CSB-PA024203
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against TAT. Recognizes TAT from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100

Tat-NR2B9c

HY-P0117 10mM/1mL
EUR 889

TAT (TFA)

HY-P0281A 5mg
EUR 712

TAT Antibody

35946-100ul 100ul
EUR 252

TAT siRNA

20-abx936139
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

TAT siRNA

20-abx936140
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

TAT siRNA

20-abx905471
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

TAT antibody

39162-100ul 100ul
EUR 252

TAT 14

B5721-1 1 mg
EUR 324

TAT Antibody

ABD8469 100 ug
EUR 438

TAT Antibody

DF8469 200ul
EUR 304
Description: TAT Antibody detects endogenous levels of total TAT.

TAT antibody

10-2250 200 ul
EUR 813
Description: Mouse monoclonal TAT antibody

Tat antibody

70R-8790 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal Tat antibody

pCEP4- tat

PVT11063 2 ug
EUR 266

TAT BROTH

T20-100-10kg 10 kg
EUR 1161

TAT BROTH

T20-100-2Kg 2 Kg
EUR 291

TAT BROTH

T20-100-500g 500 g
EUR 116

Horse TAT Complexes(TAT Complexes) ELISA Kit

QY-E120059 96T
EUR 478

Human immunodeficiency virus-Tat Protein(HIV-Tat)ELISA

GA-E1931HM-48T 48T
EUR 289

Human immunodeficiency virus-Tat Protein(HIV-Tat)ELISA

GA-E1931HM-96T 96T
EUR 466

Human immunodeficiency virus-Tat Protein (HIV-Tat) ELISA

201-12-1915 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human immunodeficiency virus-Tat Protein(HIV-Tat)ELISA

QY-E02393 96T
EUR 361

TAT cloning plasmid

CSB-CL023175HU-10ug 10ug
EUR 233
Description: A cloning plasmid for the TAT gene.

TAT stable cells

SC012 2 x 106 cell/ml x 1ml
EUR 1500
Description: Stable cell line expressing codon humanized TAT gene and RFP with Blasticidin resistance

TAT Polyclonal Antibody

ES7344-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against TAT from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

TAT Polyclonal Antibody

ES7344-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against TAT from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

SOX2-TAT, human

RC712-46 5ug
EUR 104.38

TAT (48-57)

HY-P1575 5mg
EUR 257

TAT 2-4

HY-P1579 1mg
EUR 153

NANOG-TAT, Human

HY-P7391 50ug
EUR 533

Tat-NR2B9c (TFA)

HY-P0117A 25mg
EUR 807

Anti-TAT antibody

STJ28847 100 µl
EUR 277
Description: This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked.

TAT 2-4

5-02001 4 x 1mg Ask for price

TAT Polyclonal Antibody

ABP56345-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of TAT from Human, Mouse, Rat. This TAT antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human TAT

TAT Polyclonal Antibody

ABP56345-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of TAT from Human, Mouse, Rat. This TAT antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human TAT

TAT Polyclonal Antibody

ABP56345-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of TAT from Human, Mouse, Rat. This TAT antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human TAT

TAT Rabbit pAb

A6764-100ul 100 ul
EUR 308

TAT Rabbit pAb

A6764-200ul 200 ul
EUR 459

TAT Rabbit pAb

A6764-20ul 20 ul
EUR 183

TAT Rabbit pAb

A6764-50ul 50 ul
EUR 223

Nanog-TAT Protein

20-abx262148
  • EUR 5311.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug

Anti-TAT antibody

STJ95908 200 µl
EUR 197
Description: Rabbit polyclonal to TAT.

TAT Conjugated Antibody

C35946 100ul
EUR 397

TAT 2-4

H-7648.0500 0.5mg
EUR 136
Description: Sum Formula: C132H240N66O29; CAS# [1159916-66-1] net

TAT 2-4

H-7648.1000 1.0mg
EUR 219
Description: Sum Formula: C132H240N66O29; CAS# [1159916-66-1] net

HIV1 tat antibody

20-000601 500 ul
EUR 403
Description: Rabbit polyclonal HIV1 tat antibody

HIV1 tat antibody

20-000601F 500 ul
EUR 384
Description: Rabbit polyclonal HIV1 tat antibody

HIV1 tat antibody

20-000602 100 ug
EUR 133
Description: Rabbit polyclonal HIV1 tat antibody

HIV1 tat antibody

20-HS75 50 ul
EUR 256
Description: Sheep polyclonal HIV1 tat antibody

HIV1 tat antibody

10-007001 100 ug
EUR 403
Description: Mouse monoclonal HIV1 tat antibody

HIV1 tat antibody

10-H30K 100 ug
EUR 581
Description: Mouse monoclonal HIV1 tat antibody

HIV1 tat protein

30-017001F 100 ug
EUR 1029
Description: Purified recombinant HIV1 tat protein

HIV1 tat protein

30-AH85 50 ug
EUR 960
Description: Purified recombinant HIV1 tat protein

Sox2 TAT protein

30R-AS056 25 ug
EUR 273
Description: Purified recombinant Human Sox2 TAT protein

Canine C-Peptide ELISA Kit

RD-C-Peptide-c-48Tests 48 Tests
EUR 533

Canine C-Peptide ELISA Kit

RD-C-Peptide-c-96Tests 96 Tests
EUR 740

Human C-Peptide ELISA Kit

RD-C-Peptide-Hu-48Tests 48 Tests
EUR 387

Human C-Peptide ELISA Kit

RD-C-Peptide-Hu-96Tests 96 Tests
EUR 532

Mouse C-Peptide ELISA Kit

RD-C-Peptide-Mu-48Tests 48 Tests
EUR 446

Mouse C-Peptide ELISA Kit

RD-C-Peptide-Mu-96Tests 96 Tests
EUR 615

Rat C-Peptide ELISA Kit

RD-C-Peptide-Ra-48Tests 48 Tests
EUR 465

Rat C-Peptide ELISA Kit

RD-C-Peptide-Ra-96Tests 96 Tests
EUR 643

Canine C-Peptide ELISA Kit

DLR-C-Peptide-c-48T 48T
EUR 527
Description: A competitive inhibition quantitative ELISA assay kit for detection of Canine C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Canine C-Peptide ELISA Kit

DLR-C-Peptide-c-96T 96T
EUR 688
Description: A competitive inhibition quantitative ELISA assay kit for detection of Canine C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human C-Peptide ELISA Kit

DLR-C-Peptide-Hu-48T 48T
EUR 398
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human C-Peptide ELISA Kit

DLR-C-Peptide-Hu-96T 96T
EUR 511
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse C-Peptide ELISA Kit

DLR-C-Peptide-Mu-48T 48T
EUR 450
Description: A competitive inhibition quantitative ELISA assay kit for detection of Mouse C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse C-Peptide ELISA Kit

DLR-C-Peptide-Mu-96T 96T
EUR 582
Description: A competitive inhibition quantitative ELISA assay kit for detection of Mouse C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat C-Peptide ELISA Kit

DLR-C-Peptide-Ra-48T 48T
EUR 467
Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat C-Peptide ELISA Kit

DLR-C-Peptide-Ra-96T 96T
EUR 605
Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Canine C-Peptide ELISA Kit

RDR-C-Peptide-c-48Tests 48 Tests
EUR 557

Canine C-Peptide ELISA Kit

RDR-C-Peptide-c-96Tests 96 Tests
EUR 774

Human C-Peptide ELISA Kit

RDR-C-Peptide-Hu-48Tests 48 Tests
EUR 404

Human C-Peptide ELISA Kit

RDR-C-Peptide-Hu-96Tests 96 Tests
EUR 556

Mouse C-Peptide ELISA Kit

RDR-C-Peptide-Mu-48Tests 48 Tests
EUR 465

Mouse C-Peptide ELISA Kit

RDR-C-Peptide-Mu-96Tests 96 Tests
EUR 643

Rat C-Peptide ELISA Kit

RDR-C-Peptide-Ra-48Tests 48 Tests
EUR 486

Rat C-Peptide ELISA Kit

RDR-C-Peptide-Ra-96Tests 96 Tests
EUR 672

Recombinant Tyrosine Aminotransferase (TAT)

4-RPD862Hu01
  • EUR 274.72
  • EUR 176.00
  • EUR 755.20
  • EUR 318.40
  • EUR 536.80
  • EUR 247.00
  • EUR 1738.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Tyrosine Aminotransferase expressed in: E.coli

Recombinant Tyrosine Aminotransferase (TAT)

4-RPD862Mu01
  • EUR 413.60
  • EUR 214.00
  • EUR 1276.00
  • EUR 492.00
  • EUR 884.00
  • EUR 340.00
  • EUR 3040.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Tyrosine Aminotransferase expressed in: E.coli

TAT Antibody, HRP conjugated

1-CSB-PA023175LB01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TAT. Recognizes TAT from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

TAT Antibody, FITC conjugated

1-CSB-PA023175LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TAT. Recognizes TAT from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

TAT Antibody, Biotin conjugated

1-CSB-PA023175LD01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TAT. Recognizes TAT from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Active Tyrosine Aminotransferase (TAT)

4-APD862Mu01
  • EUR 664.48
  • EUR 281.00
  • EUR 2216.80
  • EUR 805.60
  • EUR 1511.20
  • EUR 508.00
  • EUR 5392.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Tyrosine Aminotransferase expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

TAT (His) Lentiviral particles 

LVP019 5x107 IFU/ml x 200ul
EUR 349
Description: pre-made lentiviral particles expressing HIV TAT gene with N-term His tag

Sheep TAT ELISA Kit

EST0509 96Tests
EUR 521

p16-INK4a-TAT, human

RC712-35 5ug
EUR 104.38

TAT (48-57) (TFA)

HY-P1575A 5mg
EUR 257

Rat TAT ELISA Kit

ERT0509 96Tests
EUR 521

Rabbit TAT ELISA Kit

ERTT0509 96Tests
EUR 521

Monkey TAT ELISA Kit

EMKT0509 96Tests
EUR 521

Mouse TAT ELISA Kit

EMT0509 96Tests
EUR 521

Porcine TAT ELISA Kit

EPT0509 96Tests
EUR 521

Goat TAT ELISA Kit

EGTT0509 96Tests
EUR 521

Human TAT ELISA Kit

EHT0509 96Tests
EUR 521

Bovine TAT ELISA Kit

EBT0509 96Tests
EUR 521

Chicken TAT ELISA Kit

ECKT0509 96Tests
EUR 521

Canine TAT ELISA Kit

ECT0509 96Tests
EUR 521

Anserini TAT ELISA Kit

EAT0509 96Tests
EUR 521

Anti-ATTY/TAT Antibody

A00622 100ug/vial
EUR 294

Rat TAT shRNA Plasmid

20-abx984656
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Mouse TAT shRNA Plasmid

20-abx982152
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Human TAT shRNA Plasmid

20-abx954724
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Recombinant Human Nanog-TAT

7-05665 5µg Ask for price

Recombinant Human Nanog-TAT

7-05666 20µg Ask for price

Recombinant Human Nanog-TAT

7-05667 1mg Ask for price

Tyrosine Aminotransferase (TAT) Antibody

20-abx131664
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Tyrosine Aminotransferase (TAT) Antibody

20-abx131665
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

TIGAR-TAT (C12ORF5) Protein

20-abx261124
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 25 ug
  • 5 ug

TAT ELISA KIT|Human

EF005456 96 Tests
EUR 689

HIV1 tat antibody (FITC)

60-00602-3F 50 ug
EUR 540
Description: Rabbit polyclonal anti-tat HIV1 antibody (FITC)

HIV1 tat antibody (biotin)

60-00602-5 50 ug
EUR 457
Description: Rabbit polyclonal anti-tat HIV1 antibody (Biotin)

HIV1 tat protein (FITC)

65-017003F 50 ug
EUR 133
Description: Purified recombinant HIV1 tat protein (FITC)

HIV1 tat antibody (HRP)

61-007002 1 mg
EUR 381
Description: Mouse monoclonal HIV1 tat antibody (HRP)

HIV1 tat antibody (FITC)

61-007003 50 ug
EUR 178
Description: Mouse monoclonal HIV1 tat antibody (FITC)

HIV1 tat antibody (biotin)

61-007005 50 ug
EUR 349
Description: Mouse monoclonal HIV1 tat antibody (biotin)

Sox2-TAT Recombinant Protein

40-120-0005mg 0.005 mg
EUR 259.25
Description: Sox2, also known as sex determining region Y (SRY)-box 2, belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an essential role in maintaining the pluripotency of embryonic stem cells (ESC) and determination of cell fate. Microarray analysis showed that Sox2 regulates the expression of multiple genes involved in embryonic development including FGF-4, YES1 and ZFP206. Sox2 acts as a transcriptional activator after forming a ternary complex with Oct3/4 and a conserved non-coding DNA sequence (CNS1) located approximately 2 kb upstream of the RAX promoter. The introduction of Sox2, Oct4, Myc, and Klf4, into human dermal fibroblasts isolated from a skin biopsy of a healthy research fellow was sufficient to confer a pluripotent state upon the fibroblast genome. The reprogrammed cells thus obtained resemble ESC in morphology, gene expression, and in the capacity to form teratomas in immune-deficient mice. Sox2 and other transcription factors have been introduced into cells by DNA transfection, viral infection, or microinjection. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors and other nuclear proteins into primary as well as transformed cells. Recombinant human Sox2-TAT expressed in E. coli is a 36 kDa protein containing 330 amino-acid residues, including the 317 residues of full-length Sox2 and a 13-residue C-terminal TAT peptide (GGYGRKKRRQRRR).

Sox2-TAT Recombinant Protein

40-120-0025mg 0.025 mg
EUR 364.25
Description: Sox2, also known as sex determining region Y (SRY)-box 2, belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an essential role in maintaining the pluripotency of embryonic stem cells (ESC) and determination of cell fate. Microarray analysis showed that Sox2 regulates the expression of multiple genes involved in embryonic development including FGF-4, YES1 and ZFP206. Sox2 acts as a transcriptional activator after forming a ternary complex with Oct3/4 and a conserved non-coding DNA sequence (CNS1) located approximately 2 kb upstream of the RAX promoter. The introduction of Sox2, Oct4, Myc, and Klf4, into human dermal fibroblasts isolated from a skin biopsy of a healthy research fellow was sufficient to confer a pluripotent state upon the fibroblast genome. The reprogrammed cells thus obtained resemble ESC in morphology, gene expression, and in the capacity to form teratomas in immune-deficient mice. Sox2 and other transcription factors have been introduced into cells by DNA transfection, viral infection, or microinjection. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors and other nuclear proteins into primary as well as transformed cells. Recombinant human Sox2-TAT expressed in E. coli is a 36 kDa protein containing 330 amino-acid residues, including the 317 residues of full-length Sox2 and a 13-residue C-terminal TAT peptide (GGYGRKKRRQRRR).

KLF4-TAT Recombinant Protein

40-524-0005mg 0.005 mg
EUR 259.25
Description: KLF4 is a member of the Kruppel-like factor (KLF) family of zinc finger transcription factors. Members of this family have in common 3 contiguous C2H2-type zinc fingers at the carboxyl terminus that comprise the DNA-binding domain. KLF4 is highly expressed in skin and gut epithelial tissues, but is also found in various other cells and tissues, including vascular endothelial cells, lymphocytes, lung, and testis. It is an important regulator of the cell cycle, transcription, and cell differentiation. Together with Sox2, Oct4, and cMyc, KLF4 can induce the reprogramming of primary human fibroblasts to a pluripotent state. KLF4 and other transcription factors can be introduced into cells by DNA transfection, viral infection, or microinjection. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors into primary as well as transformed cells. Recombinant Human KLF4-TAT is a 483 amino acid protein, including a 13-residue C-terminal TAT peptide, with a calculated molecular weight of 51.7kDa. Recombinant Human KLF4-TAT is a mixture of the expected sequence beginning at Met1 and a truncated isoform beginning at Tyr54. Due to post-translational modifications, SDS-PAGE gel shows bands at approximately 72 and 66kDa, under reduced conditions.

KLF4-TAT Recombinant Protein

40-524-0025mg 0.025 mg
EUR 364.25
Description: KLF4 is a member of the Kruppel-like factor (KLF) family of zinc finger transcription factors. Members of this family have in common 3 contiguous C2H2-type zinc fingers at the carboxyl terminus that comprise the DNA-binding domain. KLF4 is highly expressed in skin and gut epithelial tissues, but is also found in various other cells and tissues, including vascular endothelial cells, lymphocytes, lung, and testis. It is an important regulator of the cell cycle, transcription, and cell differentiation. Together with Sox2, Oct4, and cMyc, KLF4 can induce the reprogramming of primary human fibroblasts to a pluripotent state. KLF4 and other transcription factors can be introduced into cells by DNA transfection, viral infection, or microinjection. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors into primary as well as transformed cells. Recombinant Human KLF4-TAT is a 483 amino acid protein, including a 13-residue C-terminal TAT peptide, with a calculated molecular weight of 51.7kDa. Recombinant Human KLF4-TAT is a mixture of the expected sequence beginning at Met1 and a truncated isoform beginning at Tyr54. Due to post-translational modifications, SDS-PAGE gel shows bands at approximately 72 and 66kDa, under reduced conditions.

The electrical characteristics of droplets can be modulated by controlling the number and type of layer used. Primary emulsions have the best resistance to various environmental conditions, while secondary emulsions have the worst, suggest electrostatic deposits may only be used to get certain functions. Interestingly, PLL regardless of the surface of the secondary emulsion at high salt concentrations due to electrostatic screening, which increases their salt stability. This phenomenon may be useful for several food applications, eg, have cationic droplets during food storage, but are anionic in the human body.

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