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Activation of CREB Protein With Tabersonine Attenuates STAT3 During Atherosclerosis in Apolipoprotein E-Deficient Mice.

Activation of CREB Protein With Tabersonine Attenuates STAT3 During Atherosclerosis in Apolipoprotein E-Deficient Mice.
Posted by Anna

Atherosclerosis is a pathological condition of the accumulation of fat in the arteries, leading to cardiovascular disorders. Atherosclerosis management remains a challenge and conventional medicines are used for the management of the company has several limitations. This study evaluated the effects of tabersonine protection against atherosclerosis and rated the molecular mechanisms of action.Atherosclerosis induced by feeding the apolipoprotein E (ApoE) -deficient mice a high-fat diet. Mice treated with 20 or 40 mg / kg intraperitoneally tabersonine for 12 weeks of the study. Atherosclerosis markers and nitric oxide are measured in the serum of ApoE-deficient mice. Inflammatory mediators and markers of oxidative stress were assessed using enzyme-linked immunosorbent assay tests.

Western blotting, reverse transcriptase quantitative polymerase chain reaction and immunohistochemistry analyzes were performed to determine the expression of proteins in tissue.The tabersonine-treatment group aorta had improved lipid profile and liver function improved, compared with the group treated ApoE. tabersonine treatment resulted in decreased levels of nitric oxide, cytokines, and oxidative stress, compared with ApoE.

Change expression levels of protein inhibitor activated Stat3 (PIAS3), signal transducer and activator of transcription-3 (STAT-3), and nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkBα) in ApoE mice -deficient tabersonine are helped by treatment. In addition, cAMP-response-element-binding (CREB) expression increased in aortic tissue tabersonine treatment group, compared with ApoE group.These results suggest tabersonine which ameliorates expression of Stat3 by activating CREB protein in atherosclerotic ApoE-deficient mice.

Activation of CREB Protein With Tabersonine Attenuates STAT3 During Atherosclerosis in Apolipoprotein E-Deficient Mice.
Activation of CREB Protein With Tabersonine Attenuates STAT3 During Atherosclerosis in Apolipoprotein E-Deficient Mice.

Dimethyl fumarate relieve nitroglycerin (NTG) -induced migraine in rats.

Oxidative stress and inflammatory pathways involved in migraine and endogenous antioxidant defense system have a role in hyperalgesia in migraine prevention. In this study, we aimed to evaluate the role of the molecules of the most pharmacologically effective between the ester of fumaric acid (FAEs), fumaric dimethyl, nuclear factor E2-related factor 2 / response element antioxidants (NRF-2 / ARE) pathway-mediated, in regulating hypersensitivity in a mouse model of nitroglycerin (NTG) -induced migraine.Mice administered orally with DMF at a dose of 10, 30, and 100 mg / kg, 5 minutes after intraperitoneal injection of NTG.

We did histological and molecular analysis throughout the brain and behavioral tests after 4 hours with NTG-induced migraine. The expression of nuclear factor kappa-light-chain-enhancer activated B cells (NF-кB) subunit p65, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha (IκBα), nitric oxide synthase (iNOS), cyclooxygenase 2 (COX- 2), NRF-2, manganese superoxide dismutase (Mn-SOD), and heme oxygenase – 1 (HO-1) was detected by Western blot.

Phospho-NFKBIA-S32 Rabbit pAb

AP0731-100ul 100 ul
EUR 384

Phospho-NFKBIA-S32 Rabbit pAb

AP0731-200ul 200 ul
EUR 554

Phospho-NFKBIA-S32 Rabbit pAb

AP0731-20ul 20 ul
EUR 183

Phospho-NFKBIA-S32 Rabbit pAb

AP0731-50ul 50 ul
EUR 265

Anti-Phospho-NFKBIA-(S32/36) antibody

STJ29380 100 µl
EUR 393
Description: This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Phospho-Histone H3.3-S32 Rabbit pAb

AP0486-100ul 100 ul
EUR 384

Phospho-Histone H3.3-S32 Rabbit pAb

AP0486-200ul 200 ul
EUR 554

Phospho-Histone H3.3-S32 Rabbit pAb

AP0486-20ul 20 ul
EUR 183

Phospho-Histone H3.3-S32 Rabbit pAb

AP0486-50ul 50 ul
EUR 265

Phospho-FOS (S32) Antibody

1-CSB-PA000655
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-FOS (S32). Recognizes Phospho-FOS (S32) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000

Anti-Phospho-IKB alpha (S32) Rabbit Monoclonal Antibody

P01139 100ug/vial
EUR 397
Description: Anti-Phospho-IKB alpha (S32) Rabbit Monoclonal Antibody tested for IP, WB in Human

Anti-Phospho-H3F3A-(S32) antibody

STJ29330 100 µl
EUR 393
Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family.

Polyclonal Phospho-BAD(S32) Antibody

APR09137G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Phospho-BAD(S32) . This antibody is tested and proven to work in the following applications:

IKB alpha(Phospho-S32) Antibody

13376-100ul 100ul
EUR 333

IKB alpha(Phospho-S32) Antibody

13376-50ul 50ul
EUR 239

Anti-Phospho-NFKBIA-(S32) antibody

STJ116373 100 µl
EUR 393
Description: This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Phospho-NFKBIA (S32/S36) Antibody

1-CSB-PA000559
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-NFKBIA (S32/S36). Recognizes Phospho-NFKBIA (S32/S36) from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000

Anti-Phospho-c-Fos (S32) antibody

STJ90602 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-c-Fos (S32).

IKB alpha(Phospho-S32) Conjugated Antibody

C13376 100ul
EUR 397

Anti-Phospho- kappa-alpha (S32/S36) antibody

STJ90311 200 µl
EUR 197
Description: IkappaB‚Äêalpha is a protein encoded by the NFKBIA gene which is approximately 35,6 kDa. IkappaB‚Äêalpha is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, 4-1BB pathway and toll-like receptor signalling pathways. It inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. IkappaB‚Äêalpha is expressed in adherent monocytes. Mutations in the NFKBIA gene may result in ectodermal dysplasia with T-cell immunodeficiency. STJ90311 is a synthesized peptide derived from human IkappaB-alpha around the phosphorylation site of S32/S36. This primary antibody specifically binds to endogenous IkappaB‚Äêalpha protein which only binds about S23/36 when S23/36 is phosphorylated.

Cardboard freezer box, hinged lid, insert for 36 screw-cap 5ml tubes, 5.25 x 5.25 x 3 inches

C2580-36 5/pack
EUR 63.37

HSV-?(Herpes Simplex Virus ?Antibody IgG) ELISA test

36 96T/Box Ask for price
Description: ELISA based test for quantitative detection of HSV-?(Herpes Simplex Virus ?Antibody IgG)

MRP-S32 Polyclonal Antibody

ES5644-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MRP-S32 from Human. This antibody is tested and validated for IHC, WB, ELISA

MRP-S32 Polyclonal Antibody

ES5644-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MRP-S32 from Human. This antibody is tested and validated for IHC, WB, ELISA

MRP-S32 Polyclonal Antibody

ABP54645-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of MRP-S32 from Human. This MRP-S32 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MRP-S32 at AA rangle: 50-130

MRP-S32 Polyclonal Antibody

ABP54645-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of MRP-S32 from Human. This MRP-S32 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MRP-S32 at AA rangle: 50-130

MRP-S32 Polyclonal Antibody

ABP54645-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of MRP-S32 from Human. This MRP-S32 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MRP-S32 at AA rangle: 50-130

Anti-MRP-S32 antibody

STJ94251 200 µl
EUR 197
Description: Rabbit polyclonal to MRP-S32.

Rabbit interleukin 36 alpha

ERTI0397 96Tests
EUR 521

Phospho-NFKB1-S932 Rabbit pAb

AP1064-200ul 200 ul
EUR 554

Phospho-NFKB1-S932 Rabbit pAb

AP1064-20ul 20 ul
EUR 183

Phospho-NFKB1-S932 Rabbit pAb

AP1064-50ul 50 ul
EUR 265

Phospho-ATP1A1-S16 Rabbit pAb

AP1065-100ul 100 ul
EUR 384

Phospho-ATP1A1-S16 Rabbit pAb

AP1065-200ul 200 ul
EUR 554

Phospho-ATP1A1-S16 Rabbit pAb

AP1065-20ul 20 ul
EUR 183

Phospho-ATP1A1-S16 Rabbit pAb

AP1065-50ul 50 ul
EUR 265

Phospho-CHUK-T23 Rabbit pAb

AP1066-100ul 100 ul
EUR 384

Phospho-CHUK-T23 Rabbit pAb

AP1066-200ul 200 ul
EUR 554

Phospho-CHUK-T23 Rabbit pAb

AP1066-20ul 20 ul
EUR 183

Phospho-CHUK-T23 Rabbit pAb

AP1066-50ul 50 ul
EUR 265

Phospho-NFKBIA-S36 Rabbit pAb

AP1069-100ul 100 ul
EUR 384

Phospho-NFKBIA-S36 Rabbit pAb

AP1069-200ul 200 ul
EUR 554

Phospho-NFKBIA-S36 Rabbit pAb

AP1069-20ul 20 ul
EUR 183

Phospho-NFKBIA-S36 Rabbit pAb

AP1069-50ul 50 ul
EUR 265

Phospho-ATP2A2-Thr484 Rabbit pAb

AP1070-100ul 100 ul
EUR 384

Phospho-ATP2A2-Thr484 Rabbit pAb

AP1070-200ul 200 ul
EUR 554

Phospho-ATP2A2-Thr484 Rabbit pAb

AP1070-20ul 20 ul
EUR 183

Phospho-ATP2A2-Thr484 Rabbit pAb

AP1070-50ul 50 ul
EUR 265

Phospho-BCL2-S87 Rabbit pAb

AP1071-100ul 100 ul
EUR 384

Phospho-BCL2-S87 Rabbit pAb

AP1071-200ul 200 ul
EUR 554

Phospho-BCL2-S87 Rabbit pAb

AP1071-20ul 20 ul
EUR 183

Phospho-BCL2-S87 Rabbit pAb

AP1071-50ul 50 ul
EUR 265

Phospho-DDR1-Y792 Rabbit pAb

AP1072-100ul 100 ul
EUR 384

Phospho-DDR1-Y792 Rabbit pAb

AP1072-200ul 200 ul
EUR 554

Phospho-DDR1-Y792 Rabbit pAb

AP1072-20ul 20 ul
EUR 183

Phospho-DDR1-Y792 Rabbit pAb

AP1072-50ul 50 ul
EUR 265

Phospho-CBL-Y731 Rabbit pAb

AP1073-100ul 100 ul
EUR 384

Phospho-CBL-Y731 Rabbit pAb

AP1073-200ul 200 ul
EUR 554

Phospho-CBL-Y731 Rabbit pAb

AP1073-20ul 20 ul
EUR 183

Phospho-CBL-Y731 Rabbit pAb

AP1073-50ul 50 ul
EUR 265

Phospho-CSF1R-Y723 Rabbit pAb

AP1075-100ul 100 ul
EUR 384

Phospho-CSF1R-Y723 Rabbit pAb

AP1075-200ul 200 ul
EUR 554

Phospho-CSF1R-Y723 Rabbit pAb

AP1075-20ul 20 ul
EUR 183

Phospho-CSF1R-Y723 Rabbit pAb

AP1075-50ul 50 ul
EUR 265

Phospho-CTNND1-Y904 Rabbit pAb

AP1077-100ul 100 ul
EUR 384

Phospho-CTNND1-Y904 Rabbit pAb

AP1077-200ul 200 ul
EUR 554

Phospho-CTNND1-Y904 Rabbit pAb

AP1077-20ul 20 ul
EUR 183

Phospho-CTNND1-Y904 Rabbit pAb

AP1077-50ul 50 ul
EUR 265

Phospho-CTNND1-S252 Rabbit pAb

AP1078-100ul 100 ul
EUR 384

Phospho-CTNND1-S252 Rabbit pAb

AP1078-200ul 200 ul
EUR 554

Phospho-CTNND1-S252 Rabbit pAb

AP1078-20ul 20 ul
EUR 183

Phospho-CTNND1-S252 Rabbit pAb

AP1078-50ul 50 ul
EUR 265

Phospho-CTNND1-S320 Rabbit pAb

AP1079-100ul 100 ul
EUR 384

Phospho-CTNND1-S320 Rabbit pAb

AP1079-200ul 200 ul
EUR 554

Phospho-CTNND1-S320 Rabbit pAb

AP1079-20ul 20 ul
EUR 183

Phospho-CTNND1-S320 Rabbit pAb

AP1079-50ul 50 ul
EUR 265

Phospho-DLG2-Y340 Rabbit pAb

AP1080-100ul 100 ul
EUR 384

Phospho-DLG2-Y340 Rabbit pAb

AP1080-200ul 200 ul
EUR 554

Phospho-DLG2-Y340 Rabbit pAb

AP1080-20ul 20 ul
EUR 183

Phospho-DLG2-Y340 Rabbit pAb

AP1080-50ul 50 ul
EUR 265

Phospho-EPHA2-Y588 Rabbit pAb

AP1081-100ul 100 ul
EUR 384

Phospho-EPHA2-Y588 Rabbit pAb

AP1081-200ul 200 ul
EUR 554

Phospho-EPHA2-Y588 Rabbit pAb

AP1081-20ul 20 ul
EUR 183

Phospho-EPHA2-Y588 Rabbit pAb

AP1081-50ul 50 ul
EUR 265

Phospho-EPHA2-S897 Rabbit pAb

AP1082-100ul 100 ul
EUR 384

Phospho-EPHA2-S897 Rabbit pAb

AP1082-200ul 200 ul
EUR 554

Phospho-EPHA2-S897 Rabbit pAb

AP1082-20ul 20 ul
EUR 183

Phospho-EPHA2-S897 Rabbit pAb

AP1082-50ul 50 ul
EUR 265

Phospho-PIM1-Y309 Rabbit pAb

AP1083-100ul 100 ul
EUR 384

Phospho-PIM1-Y309 Rabbit pAb

AP1083-200ul 200 ul
EUR 554

Phospho-PIM1-Y309 Rabbit pAb

AP1083-20ul 20 ul
EUR 183

Phospho-PIM1-Y309 Rabbit pAb

AP1083-50ul 50 ul
EUR 265

The tail of the film, hot plate, orofacial formalin, and photophobia tests used to evaluate migraine-like pain and light sensitivity associated with migraine. In addition, we evaluated the NRF-2-dependent mechanism in vitro stimulation of the trigeminal ganglia cells extracted by dietilenatriamina / nitric oxide (DETA / NO), nitric oxide (NO) donor. Cells pre-treated with DMF and antagonists of NRF-2, trigonelline (TR) 2 hours before treatment DETA / NO stimulation.DMF particularly reducing histological damage as shown by cresyl violet staining; Also, set both NF-kB and NRF-2 pathway, DMF treatment reduce the severity of inflammation and boost protective antioxidant action

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