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Activation of CREB Protein With Tabersonine Attenuates STAT3 During Atherosclerosis in Apolipoprotein E-Deficient Mice.

Activation of CREB Protein With Tabersonine Attenuates STAT3 During Atherosclerosis in Apolipoprotein E-Deficient Mice.
Posted by Anna

Atherosclerosis is a pathological condition of the accumulation of fat in the arteries, leading to cardiovascular disorders. Atherosclerosis management remains a challenge and conventional medicines are used for the management of the company has several limitations. This study evaluated the effects of tabersonine protection against atherosclerosis and rated the molecular mechanisms of action.Atherosclerosis induced by feeding the apolipoprotein E (ApoE) -deficient mice a high-fat diet. Mice treated with 20 or 40 mg / kg intraperitoneally tabersonine for 12 weeks of the study. Atherosclerosis markers and nitric oxide are measured in the serum of ApoE-deficient mice. Inflammatory mediators and markers of oxidative stress were assessed using enzyme-linked immunosorbent assay tests.

Western blotting, reverse transcriptase quantitative polymerase chain reaction and immunohistochemistry analyzes were performed to determine the expression of proteins in tissue.The tabersonine-treatment group aorta had improved lipid profile and liver function improved, compared with the group treated ApoE. tabersonine treatment resulted in decreased levels of nitric oxide, cytokines, and oxidative stress, compared with ApoE.

Change expression levels of protein inhibitor activated Stat3 (PIAS3), signal transducer and activator of transcription-3 (STAT-3), and nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkBα) in ApoE mice -deficient tabersonine are helped by treatment. In addition, cAMP-response-element-binding (CREB) expression increased in aortic tissue tabersonine treatment group, compared with ApoE group.These results suggest tabersonine which ameliorates expression of Stat3 by activating CREB protein in atherosclerotic ApoE-deficient mice.

Activation of CREB Protein With Tabersonine Attenuates STAT3 During Atherosclerosis in Apolipoprotein E-Deficient Mice.
Activation of CREB Protein With Tabersonine Attenuates STAT3 During Atherosclerosis in Apolipoprotein E-Deficient Mice.

Dimethyl fumarate relieve nitroglycerin (NTG) -induced migraine in rats.

Oxidative stress and inflammatory pathways involved in migraine and endogenous antioxidant defense system have a role in hyperalgesia in migraine prevention. In this study, we aimed to evaluate the role of the molecules of the most pharmacologically effective between the ester of fumaric acid (FAEs), fumaric dimethyl, nuclear factor E2-related factor 2 / response element antioxidants (NRF-2 / ARE) pathway-mediated, in regulating hypersensitivity in a mouse model of nitroglycerin (NTG) -induced migraine.Mice administered orally with DMF at a dose of 10, 30, and 100 mg / kg, 5 minutes after intraperitoneal injection of NTG.

We did histological and molecular analysis throughout the brain and behavioral tests after 4 hours with NTG-induced migraine. The expression of nuclear factor kappa-light-chain-enhancer activated B cells (NF-кB) subunit p65, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha (IκBα), nitric oxide synthase (iNOS), cyclooxygenase 2 (COX- 2), NRF-2, manganese superoxide dismutase (Mn-SOD), and heme oxygenase – 1 (HO-1) was detected by Western blot.

IκBα (phospho-Ser32) rabbit pAb

13776 100ul
EUR 319

IκBα (phospho-Ser32) rabbit pAb

E013776 100μg/100μl
EUR 255
Description: Available in various conjugation types.

IκBα (phospho-Ser32) rabbit pAb

E28PP1372 100μl
EUR 255
Description: Available in various conjugation types.

IκBα (phospho-Ser32) rabbit pAb

E44H14458 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Phospho-IκBα-S32 Rabbit mAb

AP0707 50μL
EUR 2340
Description: This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Phospho-IκBα-S32 Rabbit mAb

AP0707-100ul 100 ul
EUR 550.8

Phospho-IκBα-S32 Rabbit mAb

AP0707-200ul 200 ul Ask for price

Phospho-IκBα-S32 Rabbit mAb

AP0707-20ul 20 ul
EUR 265.2

Phospho-IκBα-S32 Rabbit mAb

AP0707-50ul 50 ul
EUR 369.6

Phospho-IκBα-S32/36 Antibody

E9P0614 100ul
EUR 255
Description: Available in various conjugation types.

Phospho-IKB alpha (S32) Rabbit pAb

E2381128 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Histone H3.3-S32 Rabbit pAb

AP0486-100ul 100 ul
EUR 460.8

Phospho-Histone H3.3-S32 Rabbit pAb

AP0486-200ul 200 ul
EUR 664.8

Phospho-Histone H3.3-S32 Rabbit pAb

AP0486-20ul 20 ul
EUR 219.6

Phospho-Histone H3.3-S32 Rabbit pAb

AP0486-50ul 50 ul
EUR 318

Phospho-IκBα-S36 Rabbit pAb

AP1069 50μL
EUR 1375.4
Description: This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Phospho-IκBα-Y42 Rabbit pAb

AP0420 200μL
EUR 113.75
Description: This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

IκBα Rabbit pAb

E2382588 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-NFKBIA-S32 Rabbit pAb

AP0731-100ul 100 ul
EUR 460.8

Phospho-NFKBIA-S32 Rabbit pAb

AP0731-200ul 200 ul
EUR 664.8

Phospho-NFKBIA-S32 Rabbit pAb

AP0731-20ul 20 ul
EUR 219.6

Phospho-NFKBIA-S32 Rabbit pAb

AP0731-50ul 50 ul
EUR 318

IκB-α (Phospho-Ser32/Ser36) Rabbit pAb

E2340776 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-IκBα-S36 Rabbit mAb

AP0999 20μL
EUR 143
Description: This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Phospho-BAD(S32) Rabbit Polyclonal Antibody

E10G32281 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Phospho-Histone H3.3-S32 pAb

E9P0486 100ul
EUR 225
Description: Available in various conjugation types.

IκBα Rabbit mAb

A19714 50μL
EUR 252.2
Description: Recombinant fusion protein containing a sequence corresponding to amino acids 25-184 of pig CD8A(XP_005662451.1)

IκB-α (phospho Ser32/S36) Rabbit Polyclonal Antibody

ES1345-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against I?B-? (phospho Ser32/S36) from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

IκB-α (phospho Ser32/S36) Rabbit Polyclonal Antibody

ES1345-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against I?B-? (phospho Ser32/S36) from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Phospho-NFKBIA-S32 pAb

E9P0731 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-p53 (S392) Rabbit pAb

E2380837 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-p53 (S376) Rabbit pAb

E2381054 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Tau (S396) Rabbit pAb

E2381213 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-HSL (S853) Rabbit pAb

E2381223 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Tau (S324) Rabbit pAb

E2381928 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Bad (S112) Rabbit pAb

E2382305 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-p53 (S33) Rabbit pAb

E2380731 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-ATM (S1981) Rabbit pAb

E2380751 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Creb (S133) Rabbit pAb

E2380697 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-HSF1 (S326) Rabbit pAb

E2380884 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-RSK1 (S380) Rabbit pAb

E2381126 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-IRE1 (S724) Rabbit pAb

E2381161 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-MSK1 (S376) Rabbit pAb

E2381219 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-SMC1 (S957) Rabbit pAb

E2381222 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Chk1 (S296) Rabbit pAb

E2381233 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-YAP1 (S127) Rabbit pAb

E2381297 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-EGFR (S695) Rabbit pAb

E2381319 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-PTEN (S380) Rabbit pAb

E2381402 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-MEK1 (S298) Rabbit pAb

E2381407 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-JunD (S255) Rabbit pAb

E2381450 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-AKT1 (S129) Rabbit pAb

E2381461 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-AKT1 (S124) Rabbit pAb

E2381479 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Raf1 (S621) Rabbit pAb

E2381495 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Raf1 (S259) Rabbit pAb

E2381497 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-IRF3 (S386) Rabbit pAb

E2381561 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-MLKL (S358) Rabbit pAb

E2382136 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-NFKB (S536) Rabbit pAb

E2619872 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Cdc6 (S54) Rabbit pAb

E2381480 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Raf1 (S43) Rabbit pAb

E2381519 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-NRF2 (S40) Rabbit pAb

E2381559 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-mTOR (S2481) Rabbit pAb

E2381548 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-mTOR (S2448) Rabbit pAb

E2381557 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-LRRK2 (S935) Rabbit pAb

E2380864 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-STAT3 (S727) Rabbit pAb

E2380906 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-eIF4E (S209) Rabbit pAb

E2381007 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-GATA3 (S308) Rabbit pAb

E2381068 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-STAT1 (S727) Rabbit pAb

E2381258 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-GluR1 (S845) Rabbit pAb

E2381354 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Smad2 (S250) Rabbit pAb

E2381410 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Smad2 (S255) Rabbit pAb

E2381412 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-SIRT1 (S47) Rabbit pAb

E2381224 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Hsp27 (S82) Rabbit pAb

E2381257 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-CDC37 (S13) Rabbit pAb

E2381484 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Hsp27 (S78) Rabbit pAb

E2381512 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-FoxO3a (S253) Rabbit pAb

E2381118 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-EIF2S1 (S51) Rabbit pAb

E2380690 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Vimentin (S72) Rabbit pAb

E2380742 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-PKA R2 (S99) Rabbit pAb

E2380704 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Smad5 (S463/465) Rabbit pAb

E2380758 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-c-Jun (S63) Rabbit pAb

E2381562 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-p95/NBS1 (S343) Rabbit pAb

E2380875 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-ER alpha (S118) Rabbit pAb

E2381180 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-DNA PKcs (S2056) Rabbit pAb

E2380800 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Smad3 (S423 + S425) Rabbit pAb

E2380775 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Smad5 (S463/S465) Rabbit pAb

E2381403 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Retinoblastoma (S780) Rabbit pAb

E2380879 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Retinoblastoma (S807) Rabbit pAb

E2381059 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-S6K1 (T421 + S424) Rabbit pAb

E2380880 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Histone H3 (S10) Rabbit pAb

E2380811 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-MYL9-T18/S19 Rabbit pAb

AP0955 100μL
EUR 323.7
Description: Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene.

Phospho-MYL9-T18/S19 Rabbit pAb

AP0955-100ul 100 ul
EUR 492

Phospho-MYL9-T18/S19 Rabbit pAb

AP0955-200ul 200 ul
EUR 685.2

Phospho-MYL9-T18/S19 Rabbit pAb

AP0955-20ul 20 ul
EUR 219.6

Phospho-MYL9-T18/S19 Rabbit pAb

AP0955-50ul 50 ul
EUR 318

Phospho-ATF2-S62/S44 Rabbit pAb

AP0127-100ul 100 ul
EUR 460.8

Phospho-ATF2-S62/S44 Rabbit pAb

AP0127-200ul 200 ul
EUR 664.8

Phospho-ATF2-S62/S44 Rabbit pAb

AP0127-20ul 20 ul Ask for price

Phospho-ATF2-S62/S44 Rabbit pAb

AP0127-50ul 50 ul
EUR 318

Phospho-Histone H2A (S129) Rabbit pAb

E2381038 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Histone H2A.X (S139) Rabbit pAb

E2381558 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-PAK1-S199/S204 Rabbit pAb

AP1125-100ul 100 ul
EUR 460.8

Phospho-PAK1-S199/S204 Rabbit pAb

AP1125-200ul 200 ul
EUR 664.8

Phospho-PAK1-S199/S204 Rabbit pAb

AP1125-20ul 20 ul
EUR 219.6

Phospho-PAK1-S199/S204 Rabbit pAb

AP1125-50ul 50 ul
EUR 318

Phospho-BRD4-S484/S488 Rabbit pAb

AP1177 1000μL
EUR 113.75
Description: The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.

Phospho-BRD4-S492/S494 Rabbit pAb

AP1178 200μL
EUR 1375.4
Description: The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.

Phospho-BRD4-S498/S499 Rabbit pAb

AP1179 100μL
EUR 1375.4
Description: The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.

Phospho-RIP3-T231/S232 Rabbit pAb

AP1260 1000μL
EUR 113.75
Description: Enables NF-kappaB-inducing kinase activity and protein serine/threonine kinase activity. Involved in several processes, including execution phase of necroptosis; hematopoietic or lymphoid organ development; and regulation of programmed cell death. Acts upstream of or within several processes, including I-kappaB kinase/NF-kappaB signaling; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of protein deacetylation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; hemolymphoid system gland; male reproductive gland or organ; primitive streak; and turbinate bone primordium. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3).

Phospho-Stathmin 1-S25 Rabbit pAb

AP0220 200μL
EUR 195
Description: This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene.

Phospho-Stathmin 1-S38 Rabbit pAb

AP0221 100μL
EUR 687.7
Description: This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene.

Phospho-Stathmin 1-S16 Rabbit pAb

AP0229 1000μL
EUR 312
Description: This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene.

Phospho-ATF2-S112/S94 Rabbit pAb

AP0130-100ul 100 ul
EUR 460.8

Phospho-ATF2-S112/S94 Rabbit pAb

AP0130-200ul 200 ul
EUR 664.8

Phospho-ATF2-S112/S94 Rabbit pAb

AP0130-20ul 20 ul Ask for price

Phospho-ATF2-S112/S94 Rabbit pAb

AP0130-50ul 50 ul
EUR 318

Phospho-Connexin 43-S368 Rabbit pAb

AP0876 500μL
EUR 57.2
Description: This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations.

IκB-β (phospho Ser23) Rabbit Polyclonal Antibody

ES1346-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against I?B-? (phospho Ser23) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

IκB-β (phospho Ser23) Rabbit Polyclonal Antibody

ES1346-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against I?B-? (phospho Ser23) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

IκB-α (phospho Tyr42) Rabbit Polyclonal Antibody

ES6380-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against I?B-? (phospho Tyr42) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IκB-α (phospho Tyr42) Rabbit Polyclonal Antibody

ES6380-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against I?B-? (phospho Tyr42) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IκB-β (phospho Thr19) Rabbit Polyclonal Antibody

ES6384-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against I?B-? (phospho Thr19) from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IκB-β (phospho Thr19) Rabbit Polyclonal Antibody

ES6384-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against I?B-? (phospho Thr19) from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IκB-ε (phospho Ser22) Rabbit Polyclonal Antibody

ES6386-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against I?B-? (phospho Ser22) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

IκB-ε (phospho Ser22) Rabbit Polyclonal Antibody

ES6386-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against I?B-? (phospho Ser22) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Phospho-Smad2-S465/S467 Rabbit pAb

AP0925 20μL
EUR 195
Description: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Phospho-SMAD2-S465/S467 Rabbit pAb

AP0925-100ul 100 ul
EUR 460.8

Phospho-SMAD2-S465/S467 Rabbit pAb

AP0925-200ul 200 ul
EUR 664.8

Phospho-SMAD2-S465/S467 Rabbit pAb

AP0925-20ul 20 ul
EUR 219.6

Phospho-SMAD2-S465/S467 Rabbit pAb

AP0925-50ul 50 ul
EUR 318

Phospho-Smad3-S423/S425 Rabbit pAb

AP1263 1000μL
EUR 113.75
Description: The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. This protein forms a complex with other SMAD proteins and binds DNA, functioning both as a transcription factor and tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3.

Phospho-Smad5-S463/S465 Rabbit pAb

AP1319 50μL
EUR 195
Description: The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants.

IκB-α (phospho Tyr305) Rabbit Polyclonal Antibody

ES6381-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against I?B-? (phospho Tyr305) from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IκB-α (phospho Tyr305) Rabbit Polyclonal Antibody

ES6381-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against I?B-? (phospho Tyr305) from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Phospho-NMDAR1-S896/S897 Rabbit pAb

AP0962 20μL
EUR 323.7
Description: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

Phospho-IFNAR1-S535/S539 Rabbit pAb

AP0366-100ul 100 ul
EUR 460.8

Phospho-IFNAR1-S535/S539 Rabbit pAb

AP0366-200ul 200 ul
EUR 664.8

Phospho-IFNAR1-S535/S539 Rabbit pAb

AP0366-20ul 20 ul Ask for price

Phospho-IFNAR1-S535/S539 Rabbit pAb

AP0366-50ul 50 ul
EUR 318

Phospho-IL10RA-S319/S323 Rabbit pAb

AP0370-100ul 100 ul
EUR 460.8

Phospho-IL10RA-S319/S323 Rabbit pAb

AP0370-200ul 200 ul
EUR 664.8

Phospho-IL10RA-S319/S323 Rabbit pAb

AP0370-20ul 20 ul Ask for price

Phospho-IL10RA-S319/S323 Rabbit pAb

AP0370-50ul 50 ul
EUR 318

Phospho-P90RSK-T359/S363 Rabbit pAb

AP0539-100ul 100 ul
EUR 460.8

Phospho-P90RSK-T359/S363 Rabbit pAb

AP0539-200ul 200 ul
EUR 664.8

Phospho-P90RSK-T359/S363 Rabbit pAb

AP0539-20ul 20 ul
EUR 219.6

Phospho-P90RSK-T359/S363 Rabbit pAb

AP0539-50ul 50 ul
EUR 318

Phospho-PKCδ/θ-S643/676 Rabbit pAb

E2500567 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-IKKα/β-S176/180 Rabbit pAb

AP0891 50μL
EUR 57.2
Description: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]

Phospho-IKKα/β-S176/180 Rabbit pAb

AP0891-100ul 100 ul
EUR 460.8

Phospho-IKKα/β-S176/180 Rabbit pAb

AP0891-200ul 200 ul
EUR 664.8

Phospho-IKKα/β-S176/180 Rabbit pAb

AP0891-20ul 20 ul
EUR 219.6

Phospho-IKKα/β-S176/180 Rabbit pAb

AP0891-50ul 50 ul
EUR 318

Phospho-IKKα/β-S176/180 Rabbit pAb

AP0546 20μL
EUR 687.7
Description: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]

Phospho-IKKα/β-S176/180 Rabbit pAb

AP0546-100ul 100 ul
EUR 460.8

Phospho-IKKα/β-S176/180 Rabbit pAb

AP0546-200ul 200 ul
EUR 664.8

Phospho-IKKα/β-S176/180 Rabbit pAb

AP0546-20ul 20 ul
EUR 219.6

Phospho-IKKα/β-S176/180 Rabbit pAb

AP0546-50ul 50 ul
EUR 318

The tail of the film, hot plate, orofacial formalin, and photophobia tests used to evaluate migraine-like pain and light sensitivity associated with migraine. In addition, we evaluated the NRF-2-dependent mechanism in vitro stimulation of the trigeminal ganglia cells extracted by dietilenatriamina / nitric oxide (DETA / NO), nitric oxide (NO) donor. Cells pre-treated with DMF and antagonists of NRF-2, trigonelline (TR) 2 hours before treatment DETA / NO stimulation.DMF particularly reducing histological damage as shown by cresyl violet staining; Also, set both NF-kB and NRF-2 pathway, DMF treatment reduce the severity of inflammation and boost protective antioxidant action

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