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Activation of CREB Protein With Tabersonine Attenuates STAT3 During Atherosclerosis in Apolipoprotein E-Deficient Mice.

Activation of CREB Protein With Tabersonine Attenuates STAT3 During Atherosclerosis in Apolipoprotein E-Deficient Mice.
Posted by Anna

Atherosclerosis is a pathological condition of the accumulation of fat in the arteries, leading to cardiovascular disorders. Atherosclerosis management remains a challenge and conventional medicines are used for the management of the company has several limitations. This study evaluated the effects of tabersonine protection against atherosclerosis and rated the molecular mechanisms of action.Atherosclerosis induced by feeding the apolipoprotein E (ApoE) -deficient mice a high-fat diet. Mice treated with 20 or 40 mg / kg intraperitoneally tabersonine for 12 weeks of the study. Atherosclerosis markers and nitric oxide are measured in the serum of ApoE-deficient mice. Inflammatory mediators and markers of oxidative stress were assessed using enzyme-linked immunosorbent assay tests.

Western blotting, reverse transcriptase quantitative polymerase chain reaction and immunohistochemistry analyzes were performed to determine the expression of proteins in tissue.The tabersonine-treatment group aorta had improved lipid profile and liver function improved, compared with the group treated ApoE. tabersonine treatment resulted in decreased levels of nitric oxide, cytokines, and oxidative stress, compared with ApoE.

Change expression levels of protein inhibitor activated Stat3 (PIAS3), signal transducer and activator of transcription-3 (STAT-3), and nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkBα) in ApoE mice -deficient tabersonine are helped by treatment. In addition, cAMP-response-element-binding (CREB) expression increased in aortic tissue tabersonine treatment group, compared with ApoE group.These results suggest tabersonine which ameliorates expression of Stat3 by activating CREB protein in atherosclerotic ApoE-deficient mice.

Activation of CREB Protein With Tabersonine Attenuates STAT3 During Atherosclerosis in Apolipoprotein E-Deficient Mice.
Activation of CREB Protein With Tabersonine Attenuates STAT3 During Atherosclerosis in Apolipoprotein E-Deficient Mice.

Dimethyl fumarate relieve nitroglycerin (NTG) -induced migraine in rats.

Oxidative stress and inflammatory pathways involved in migraine and endogenous antioxidant defense system have a role in hyperalgesia in migraine prevention. In this study, we aimed to evaluate the role of the molecules of the most pharmacologically effective between the ester of fumaric acid (FAEs), fumaric dimethyl, nuclear factor E2-related factor 2 / response element antioxidants (NRF-2 / ARE) pathway-mediated, in regulating hypersensitivity in a mouse model of nitroglycerin (NTG) -induced migraine.Mice administered orally with DMF at a dose of 10, 30, and 100 mg / kg, 5 minutes after intraperitoneal injection of NTG.

We did histological and molecular analysis throughout the brain and behavioral tests after 4 hours with NTG-induced migraine. The expression of nuclear factor kappa-light-chain-enhancer activated B cells (NF-кB) subunit p65, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha (IκBα), nitric oxide synthase (iNOS), cyclooxygenase 2 (COX- 2), NRF-2, manganese superoxide dismutase (Mn-SOD), and heme oxygenase – 1 (HO-1) was detected by Western blot.

Phospho-NFKBIA-S32 Rabbit pAb

AP0731-100ul 100 ul
EUR 460.8

Phospho-NFKBIA-S32 Rabbit pAb

AP0731-200ul 200 ul
EUR 664.8

Phospho-NFKBIA-S32 Rabbit pAb

AP0731-20ul 20 ul
EUR 219.6

Phospho-NFKBIA-S32 Rabbit pAb

AP0731-50ul 50 ul
EUR 318

Anti-Phospho-NFKBIA-(S32/36) antibody

STJ29380 100 µl
EUR 471.6
Description: This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Phospho-Histone H3.3-S32 Rabbit pAb

AP0486-100ul 100 ul
EUR 460.8

Phospho-Histone H3.3-S32 Rabbit pAb

AP0486-200ul 200 ul
EUR 664.8

Phospho-Histone H3.3-S32 Rabbit pAb

AP0486-20ul 20 ul
EUR 219.6

Phospho-Histone H3.3-S32 Rabbit pAb

AP0486-50ul 50 ul
EUR 318

Phospho-FOS (S32) Antibody

1-CSB-PA000655
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-FOS (S32). Recognizes Phospho-FOS (S32) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000

Anti-Phospho-IKB alpha (S32) Rabbit Monoclonal Antibody

P01139 100ug/vial
EUR 476.4
Description: Anti-Phospho-IKB alpha (S32) Rabbit Monoclonal Antibody tested for IP, WB in Human

IKB alpha(Phospho-S32) Antibody

13376-100ul 100ul
EUR 399.6

IKB alpha(Phospho-S32) Antibody

13376-50ul 50ul
EUR 286.8

Polyclonal Phospho-BAD(S32) Antibody

APR09137G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Phospho-BAD(S32) . This antibody is tested and proven to work in the following applications:

Phospho-NFKBIA (S32/S36) Antibody

1-CSB-PA000559
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-NFKBIA (S32/S36). Recognizes Phospho-NFKBIA (S32/S36) from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000

Anti-Phospho-NFKBIA-(S32) antibody

STJ116373 100 µl
EUR 471.6
Description: This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Anti-Phospho-H3F3A-(S32) antibody

STJ29330 100 µl
EUR 471.6
Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family.

IKB alpha(Phospho-S32) Conjugated Antibody

C13376 100ul
EUR 476.4

Anti-Phospho-c-Fos (S32) antibody

STJ90602 200 µl
EUR 236.4
Description: Rabbit polyclonal to Phospho-c-Fos (S32).

Anti-Phospho- kappa-alpha (S32/S36) antibody

STJ90311 200 µl
EUR 236.4
Description: IkappaB‚Äêalpha is a protein encoded by the NFKBIA gene which is approximately 35,6 kDa. IkappaB‚Äêalpha is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, 4-1BB pathway and toll-like receptor signalling pathways. It inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. IkappaB‚Äêalpha is expressed in adherent monocytes. Mutations in the NFKBIA gene may result in ectodermal dysplasia with T-cell immunodeficiency. STJ90311 is a synthesized peptide derived from human IkappaB-alpha around the phosphorylation site of S32/S36. This primary antibody specifically binds to endogenous IkappaB‚Äêalpha protein which only binds about S23/36 when S23/36 is phosphorylated.

Cardboard freezer box, hinged lid, insert for 36 screw-cap 5ml tubes, 5.25 x 5.25 x 3 inches

C2580-36 5/pack
EUR 76.04

HSV-?(Herpes Simplex Virus ?Antibody IgG) ELISA test

36 96T/Box Ask for price
Description: ELISA based test for quantitative detection of HSV-?(Herpes Simplex Virus ?Antibody IgG)

Phospho-FOXO1-S319 Rabbit pAb

AP0176-200ul 200 ul
EUR 664.8

Phospho-FOXO1-S319 Rabbit pAb

AP0176-20ul 20 ul Ask for price

Phospho-FOXO1-S319 Rabbit pAb

AP0176-50ul 50 ul
EUR 318

Phospho-FOXO4-S197 Rabbit pAb

AP0177-100ul 100 ul
EUR 460.8

Phospho-FOXO4-S197 Rabbit pAb

AP0177-200ul 200 ul
EUR 664.8

Phospho-FOXO4-S197 Rabbit pAb

AP0177-20ul 20 ul
EUR 219.6

Phospho-FOXO4-S197 Rabbit pAb

AP0177-50ul 50 ul
EUR 318

Phospho-CFL1-S3 Rabbit pAb

AP0178-100ul 100 ul
EUR 460.8

Phospho-CFL1-S3 Rabbit pAb

AP0178-200ul 200 ul
EUR 664.8

Phospho-CFL1-S3 Rabbit pAb

AP0178-20ul 20 ul
EUR 219.6

Phospho-CFL1-S3 Rabbit pAb

AP0178-50ul 50 ul
EUR 318

Phospho-CHEK1-S280 Rabbit pAb

AP0179-100ul 100 ul
EUR 460.8

Phospho-CHEK1-S280 Rabbit pAb

AP0179-200ul 200 ul
EUR 664.8

Phospho-CHEK1-S280 Rabbit pAb

AP0179-20ul 20 ul Ask for price

Phospho-CHEK1-S280 Rabbit pAb

AP0179-50ul 50 ul
EUR 318

Phospho-VAV1-Y174 Rabbit pAb

AP0180-100ul 100 ul
EUR 460.8

Phospho-VAV1-Y174 Rabbit pAb

AP0180-200ul 200 ul
EUR 664.8

Phospho-VAV1-Y174 Rabbit pAb

AP0180-20ul 20 ul Ask for price

Phospho-VAV1-Y174 Rabbit pAb

AP0180-50ul 50 ul
EUR 318

Phospho-IRS1-S312 Rabbit pAb

AP0181-100ul 100 ul
EUR 460.8

Phospho-IRS1-S312 Rabbit pAb

AP0181-200ul 200 ul
EUR 664.8

Phospho-IRS1-S312 Rabbit pAb

AP0181-20ul 20 ul Ask for price

Phospho-IRS1-S312 Rabbit pAb

AP0181-50ul 50 ul
EUR 318

Phospho-LCK-Y394 Rabbit pAb

AP0182-100ul 100 ul
EUR 460.8

Phospho-LCK-Y394 Rabbit pAb

AP0182-200ul 200 ul
EUR 664.8

Phospho-LCK-Y394 Rabbit pAb

AP0182-20ul 20 ul Ask for price

Phospho-LCK-Y394 Rabbit pAb

AP0182-50ul 50 ul
EUR 318

Phospho-SRC-Y529 Rabbit pAb

AP0185-100ul 100 ul
EUR 460.8

Phospho-SRC-Y529 Rabbit pAb

AP0185-200ul 200 ul
EUR 664.8

Phospho-SRC-Y529 Rabbit pAb

AP0185-20ul 20 ul
EUR 219.6

Phospho-SRC-Y529 Rabbit pAb

AP0185-50ul 50 ul
EUR 318

Phospho-PAK1-T212 Rabbit pAb

AP0186-100ul 100 ul
EUR 460.8

Phospho-PAK1-T212 Rabbit pAb

AP0186-200ul 200 ul
EUR 664.8

Phospho-PAK1-T212 Rabbit pAb

AP0186-20ul 20 ul Ask for price

Phospho-PAK1-T212 Rabbit pAb

AP0186-50ul 50 ul
EUR 318

Phospho-VASP-S239 Rabbit pAb

AP0187-100ul 100 ul
EUR 460.8

Phospho-VASP-S239 Rabbit pAb

AP0187-200ul 200 ul
EUR 664.8

Phospho-VASP-S239 Rabbit pAb

AP0187-20ul 20 ul
EUR 219.6

Phospho-VASP-S239 Rabbit pAb

AP0187-50ul 50 ul
EUR 318

Phospho-MAP2K1-S221 Rabbit pAb

AP0188-100ul 100 ul
EUR 460.8

Phospho-MAP2K1-S221 Rabbit pAb

AP0188-200ul 200 ul
EUR 664.8

Phospho-MAP2K1-S221 Rabbit pAb

AP0188-20ul 20 ul Ask for price

Phospho-MAP2K1-S221 Rabbit pAb

AP0188-50ul 50 ul
EUR 318

Phospho-HSPB1-S15 Rabbit pAb

AP0189-100ul 100 ul
EUR 460.8

Phospho-HSPB1-S15 Rabbit pAb

AP0189-200ul 200 ul
EUR 664.8

Phospho-HSPB1-S15 Rabbit pAb

AP0189-20ul 20 ul Ask for price

Phospho-HSPB1-S15 Rabbit pAb

AP0189-50ul 50 ul
EUR 318

Phospho-PRKCQ-S695 Rabbit pAb

AP0192-100ul 100 ul
EUR 460.8

Phospho-PRKCQ-S695 Rabbit pAb

AP0192-200ul 200 ul
EUR 664.8

Phospho-PRKCQ-S695 Rabbit pAb

AP0192-20ul 20 ul Ask for price

Phospho-PRKCQ-S695 Rabbit pAb

AP0192-50ul 50 ul
EUR 318

Phospho-MAP3K5-S966 Rabbit pAb

AP0194-100ul 100 ul
EUR 460.8

Phospho-MAP3K5-S966 Rabbit pAb

AP0194-200ul 200 ul
EUR 664.8

Phospho-MAP3K5-S966 Rabbit pAb

AP0194-20ul 20 ul Ask for price

Phospho-MAP3K5-S966 Rabbit pAb

AP0194-50ul 50 ul
EUR 318

Phospho-YWHAZ-S58 Rabbit pAb

AP0195-100ul 100 ul
EUR 460.8

Phospho-YWHAZ-S58 Rabbit pAb

AP0195-200ul 200 ul
EUR 664.8

Phospho-YWHAZ-S58 Rabbit pAb

AP0195-20ul 20 ul Ask for price

Phospho-YWHAZ-S58 Rabbit pAb

AP0195-50ul 50 ul
EUR 318

Phospho-ADD1-S726 Rabbit pAb

AP0196-100ul 100 ul
EUR 460.8

Phospho-ADD1-S726 Rabbit pAb

AP0196-200ul 200 ul
EUR 664.8

Phospho-ADD1-S726 Rabbit pAb

AP0196-20ul 20 ul Ask for price

Phospho-ADD1-S726 Rabbit pAb

AP0196-50ul 50 ul
EUR 318

Phospho-EGFR-T678 Rabbit pAb

AP0198-100ul 100 ul
EUR 460.8

Phospho-EGFR-T678 Rabbit pAb

AP0198-200ul 200 ul
EUR 664.8

Phospho-EGFR-T678 Rabbit pAb

AP0198-20ul 20 ul Ask for price

Phospho-EGFR-T678 Rabbit pAb

AP0198-50ul 50 ul
EUR 318

Phospho-EGFR-T693 Rabbit pAb

AP0199-100ul 100 ul
EUR 460.8

Phospho-EGFR-T693 Rabbit pAb

AP0199-200ul 200 ul
EUR 664.8

Phospho-EGFR-T693 Rabbit pAb

AP0199-20ul 20 ul Ask for price

Phospho-EGFR-T693 Rabbit pAb

AP0199-50ul 50 ul
EUR 318

Phospho-APP-T668 Rabbit pAb

AP0200-100ul 100 ul
EUR 460.8

Phospho-APP-T668 Rabbit pAb

AP0200-200ul 200 ul
EUR 664.8

Phospho-APP-T668 Rabbit pAb

AP0200-20ul 20 ul Ask for price

Phospho-APP-T668 Rabbit pAb

AP0200-50ul 50 ul
EUR 318

Phospho-HDAC2-S394 Rabbit pAb

AP0201-100ul 100 ul
EUR 460.8

Phospho-HDAC2-S394 Rabbit pAb

AP0201-200ul 200 ul
EUR 664.8

Phospho-HDAC2-S394 Rabbit pAb

AP0201-20ul 20 ul Ask for price

Phospho-HDAC2-S394 Rabbit pAb

AP0201-50ul 50 ul
EUR 318

Phospho-HDAC5-S498 Rabbit pAb

AP0202-100ul 100 ul
EUR 460.8

Phospho-HDAC5-S498 Rabbit pAb

AP0202-200ul 200 ul
EUR 664.8

Phospho-HDAC5-S498 Rabbit pAb

AP0202-20ul 20 ul Ask for price

Phospho-HDAC5-S498 Rabbit pAb

AP0202-50ul 50 ul
EUR 318

Phospho-HSP90AB1-S254 Rabbit pAb

AP0203-100ul 100 ul
EUR 460.8

Phospho-HSP90AB1-S254 Rabbit pAb

AP0203-200ul 200 ul
EUR 664.8

Phospho-HSP90AB1-S254 Rabbit pAb

AP0203-20ul 20 ul Ask for price

Phospho-HSP90AB1-S254 Rabbit pAb

AP0203-50ul 50 ul
EUR 318

Phospho-SMC1A-S957 Rabbit pAb

AP0204-100ul 100 ul
EUR 460.8

Phospho-SMC1A-S957 Rabbit pAb

AP0204-200ul 200 ul
EUR 664.8

Phospho-SMC1A-S957 Rabbit pAb

AP0204-20ul 20 ul Ask for price

Phospho-SMC1A-S957 Rabbit pAb

AP0204-50ul 50 ul
EUR 318

Phospho-BCR-Y177 Rabbit pAb

AP0205-100ul 100 ul
EUR 460.8

Phospho-BCR-Y177 Rabbit pAb

AP0205-200ul 200 ul
EUR 664.8

Phospho-BCR-Y177 Rabbit pAb

AP0205-20ul 20 ul Ask for price

Phospho-BCR-Y177 Rabbit pAb

AP0205-50ul 50 ul
EUR 318

Phospho-PXN-Y31 Rabbit pAb

AP0206-100ul 100 ul
EUR 460.8

Phospho-PXN-Y31 Rabbit pAb

AP0206-200ul 200 ul
EUR 664.8

Phospho-PXN-Y31 Rabbit pAb

AP0206-20ul 20 ul Ask for price

Phospho-PXN-Y31 Rabbit pAb

AP0206-50ul 50 ul
EUR 318

Phospho-EZR-T567 Rabbit pAb

AP0207-100ul 100 ul
EUR 460.8

Phospho-EZR-T567 Rabbit pAb

AP0207-200ul 200 ul
EUR 664.8

Phospho-EZR-T567 Rabbit pAb

AP0207-20ul 20 ul Ask for price

Phospho-EZR-T567 Rabbit pAb

AP0207-50ul 50 ul
EUR 318

Phospho-TH-S31 Rabbit pAb

AP0210-100ul 100 ul
EUR 460.8

Phospho-TH-S31 Rabbit pAb

AP0210-200ul 200 ul
EUR 664.8

Phospho-TH-S31 Rabbit pAb

AP0210-20ul 20 ul Ask for price

Phospho-TH-S31 Rabbit pAb

AP0210-50ul 50 ul
EUR 318

Phospho-TH-S40 Rabbit pAb

AP0211-100ul 100 ul
EUR 460.8

Phospho-TH-S40 Rabbit pAb

AP0211-200ul 200 ul
EUR 664.8

Phospho-TH-S40 Rabbit pAb

AP0211-20ul 20 ul Ask for price

Phospho-TH-S40 Rabbit pAb

AP0211-50ul 50 ul
EUR 318

Phospho-NFKBIE-S22 Rabbit pAb

AP0212-100ul 100 ul
EUR 460.8

Phospho-NFKBIE-S22 Rabbit pAb

AP0212-200ul 200 ul
EUR 664.8

Phospho-NFKBIE-S22 Rabbit pAb

AP0212-20ul 20 ul Ask for price

Phospho-NFKBIE-S22 Rabbit pAb

AP0212-50ul 50 ul
EUR 318

Phospho-PTK2B-Y402 Rabbit pAb

AP0214-100ul 100 ul
EUR 460.8

Phospho-PTK2B-Y402 Rabbit pAb

AP0214-200ul 200 ul
EUR 664.8

Phospho-PTK2B-Y402 Rabbit pAb

AP0214-20ul 20 ul Ask for price

Phospho-PTK2B-Y402 Rabbit pAb

AP0214-50ul 50 ul
EUR 318

Phospho-EGFR-Y1172 Rabbit pAb

AP0218-100ul 100 ul
EUR 460.8

Phospho-EGFR-Y1172 Rabbit pAb

AP0218-200ul 200 ul
EUR 664.8

Phospho-EGFR-Y1172 Rabbit pAb

AP0218-20ul 20 ul Ask for price

Phospho-EGFR-Y1172 Rabbit pAb

AP0218-50ul 50 ul
EUR 318

Phospho-EIF4EBP1-T45 Rabbit pAb

AP0219-100ul 100 ul
EUR 460.8

Phospho-EIF4EBP1-T45 Rabbit pAb

AP0219-200ul 200 ul
EUR 664.8

Phospho-EIF4EBP1-T45 Rabbit pAb

AP0219-20ul 20 ul Ask for price

Phospho-EIF4EBP1-T45 Rabbit pAb

AP0219-50ul 50 ul
EUR 318

Phospho-STMN1-S25 Rabbit pAb

AP0220-100ul 100 ul
EUR 460.8

Phospho-STMN1-S25 Rabbit pAb

AP0220-200ul 200 ul
EUR 664.8

Phospho-STMN1-S25 Rabbit pAb

AP0220-20ul 20 ul
EUR 219.6

Phospho-STMN1-S25 Rabbit pAb

AP0220-50ul 50 ul
EUR 318

Phospho-STMN1-S38 Rabbit pAb

AP0221-100ul 100 ul
EUR 460.8

Phospho-STMN1-S38 Rabbit pAb

AP0221-200ul 200 ul
EUR 664.8

Phospho-STMN1-S38 Rabbit pAb

AP0221-20ul 20 ul
EUR 219.6

Phospho-STMN1-S38 Rabbit pAb

AP0221-50ul 50 ul
EUR 318

The tail of the film, hot plate, orofacial formalin, and photophobia tests used to evaluate migraine-like pain and light sensitivity associated with migraine. In addition, we evaluated the NRF-2-dependent mechanism in vitro stimulation of the trigeminal ganglia cells extracted by dietilenatriamina / nitric oxide (DETA / NO), nitric oxide (NO) donor. Cells pre-treated with DMF and antagonists of NRF-2, trigonelline (TR) 2 hours before treatment DETA / NO stimulation.DMF particularly reducing histological damage as shown by cresyl violet staining; Also, set both NF-kB and NRF-2 pathway, DMF treatment reduce the severity of inflammation and boost protective antioxidant action

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